| Geno
|
Mag
|
Summary
|
| (C;C)
|
0
|
common/normal
|
| (C;G)
|
2
|
Somewhat more likely to prefer staying up late
|
| (G;G)
|
2
|
Somewhat more likely to prefer staying up late
|
Based on a study of 182 DSPT individuals, 67 free-running type (FRT) individuals, and 925 controls, all of whom were Japanese and between the ages of 20-40, a 2014 study concluded that rs228697(C;C) individuals were more likely to be "morning types" than "evening types", while rs228697(G) carriers were more common in evening types than in morning types (OR: 2.483; CI: 1.339–4.603, Bonferroni-corrected p = 0.012; crude p = 0.004). Similarly, the frequency of the G allele for rs228697 was significantly increased in FRT individuals compared with controls (OR: 2.021; CI: 1.160–3.524; permutated p = 0.017; crude p = 0.011).[PMID 25201053
]
[PMID 25201053] Screening of clock gene polymorphisms demonstrates association of a PER3 polymorphism with morningness-eveningness preference and circadian rhythm sleep disorder.
]
