|(A;G)||2||1.5x increased risk for stomach & esophageal cancer (seen in Han Chinese)|
|(G;G)||2.4||1.9x increased risk for stomach & esophageal cancer (seen in Han Chinese)|
In a large study of Han Chinese esophageal cancer patients [specifically esophageal squamous cell carcinoma (ESCC)], the rs2274223(G) allele was associated with greater risk (odds ratio 1.43, p = 7.4 x 10e-56).PMID 21689432] Association between novel PLCE1 variants identified in published esophageal cancer genome-wide association studies and risk of squamous cell carcinoma of the head and neck
|Title||Genome-wide association study identifies three new susceptibility loci for esophageal squamous-cell carcinoma in Chinese populations.|
|Odds Ratio||1.3400 [1.26-1.42]|
[PMID 21837401] Genetic variation in PLCE1 is associated with gastric cancer survival in a Chinese population
[PMID 22203178] Putatively Functional PLCE1 Variants and Susceptibility to Esophageal Squamous Cell Carcinoma (ESCC): A Case-Control Study in Eastern Chinese Populations
[PMID 22412849] Potentially Functional Variants of PLCE1 Identified by GWASs Contribute to Gastric Adenocarcinoma Susceptibility in an Eastern Chinese Population
[PMID 22744421] Replication study of PLCE1 and C20orf54 polymorphism and risk of esophageal cancer in a Chinese population
[PMID 16385451] A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease.
[PMID 20729852] A shared susceptibility locus in PLCE1 at 10q23 for gastric adenocarcinoma and esophageal squamous cell carcinoma.
[PMID 21427165] Genetic variants at 1q22 and 10q23 reproducibly associated with gastric cancer susceptibility in a Chinese population.
[PMID 23079034] PLC-ε1 Gene Polymorphisms Significantly Enhance the Risk of Esophageal Squamous Cell Carcinoma in Individuals with a Family History of Upper Gastrointestinal Cancers
|qualified_impact||Insufficiently evaluated not reviewed|
[PMID 23151416] Genetic variants at 10q23 are associated with risk of head and neck cancer in a Chinese population
[PMID 23390063] A sequence variant in the phospholipase C epsilon C2 domain is associated with esophageal carcinoma and esophagitis
[PMID 23688607] Novel functional variants locus in PLCE1 and susceptibility to esophageal squamous cell carcinoma: Based on published genome-wide association studies in a central Chinese population
[PMID 24069371] Helicobacter pylori Infection Synergizes with Three Inflammation-Related Genetic Variants in the GWASs to Increase Risk of Gastric Cancer in a Chinese Population
[PMID 24116107] Increased Risk of Developing Digestive Tract Cancer in Subjects Carrying the PLCE1 rs2274223 A>G Polymorphism: Evidence from a Meta-Analysis
[PMID 24127316] Heterozygote of PLCE1 rs2274223 increases susceptibility to human papillomavirus infection in patients with esophageal carcinoma among the Kazakh populations
[PMID 22740136] Association of 10q23 with colorectal cancer in a Chinese population.
[PMID 22805490] Genetic variation in C20orf54, PLCE1 and MUC1 and the risk of upper gastrointestinal cancers in Caucasian populations.
[PMID 23797815] PLCE1 rs2274223 A>G polymorphism and cancer risk: a meta-analysis.
[PMID 24863943] A multigenic approach to evaluate genetic variants of PLCE1, LXRs, MMPs, TIMP, and CYP genes in gallbladder cancer predisposition
[PMID 24935391] Phospholipase C Epsilon 1 (PLCE1 rs2274223A>G, rs3765524C>T and rs7922612C>T) Polymorphisms and Esophageal Cancer Risk in the Kashmir Valley
[PMID 25139097] Role of novel and GWAS originated PLCE1 genetic variants in susceptibility and prognosis of esophageal cancer patients in northern Indian population
[PMID 25503145] PSCA and MUC1 Gene Polymorphisms Are Linked with Gastric Cancer and Pre-malignant Gastric Conditions
[PMID 25008389] HPV seropositivity joints with susceptibility loci identified in GWASs at apoptosis associated genes to increase the risk of Esophageal Squamous Cell Carcinoma (ESCC)
[PMID 25854357] PLCE1 Gene in Esophageal Cancer and Interaction with Environmental Factors
[PMID 25992311] Genetic variants and risk of gastric cancer: a pathway analysis of a genome-wide association study
[PMID 26320491] Common Genetic Variants of PSCA, MUC1 and PLCE1 Genes are not Associated with Colorectal Cancer