Adiponectin signaling status was assigned as follows:
rs1501299(G,G) + rs2241766(T,T) = low signaler
rs1501299(G,T) + rs2241766(T,T) = low signaler
rs1501299(G,G) + rs2241766(G,T) = low signaler
rs1501299(T,T) + rs2241766(T,T) = intermediate signaler
rs1501299(G,T) + rs2241766(G,T) = intermediate signaler
rs1501299(G,G) + rs2241766(G,G) = intermediate signaler
rs1501299(G,T) + rs2241766(G,G) = high signaler
rs1501299(T,T) + rs2241766(G,G) = high signaler
rs1501299(T,T) + rs2241766(G,T) = high signaler
Based on these criteria, adiponectin signaling status is now determined by genosets Gs119 and Gs120 for Promethease users.
Note that adiponectin, a hormone produced by adipose tissue (body fat), is involved in lipid metabolism.
In other words, you are a low adiponectin signaler, and thus possibly at 6-fold higher risk of breast cancer, if you have one of these combinations of alleles:
You are an intermediate adiponectin signaler, and thus possibly at 4-fold higher risk of breast cancer, if you have one of these combinations of alleles:
- rs1501299 GG and also rs2241766 GG
- rs1501299 GT and also rs2241766 GT
- rs1501299 TT and also rs2241766 TT
You are a high adiponectin signaler if you have one of these combinations of alleles:PMID 19573164] Association Study and Mutation Analysis of Adiponectin Shows Association of Variants in APM1 with Complex Obesity in Women [PMID 19696691] Low Serum Adiponectin Levels Are Associated With Systemic Organ Failure in Acute Pancreatitis
[PMID 19631916] Association study of the single nucleotide polymorphisms in adiponectin-associated genes with type 2 diabetes in Han Chinese
[PMID 20414354] Analysis of adiponectin gene polymorphisms in chinese population with systemic lupus erythematosus
[PMID 20576642] Adiponectin gene polymorphisms and their effect on the risk of myocardial infarction and type 2 diabetes: an association study in an Italian population
[PMID 20664545] Relationships among adiponectin gene polymorphisms, proteinuria and increased blood pressure in the context of placental diseases
[PMID 21397927] Polymorphisms of ADIPOQ and ADIPOR1 and prostate cancer risk
[PMID 21516303] Common genetic variation in adiponectin, leptin, and leptin receptor and association with breast cancer subtypes
[PMID 21619462] The role of adiponectin (ADIPOQ) gene polymorphisms in the susceptibility and prognosis of non-small cell lung cancer
[PMID 21630088] Genetic effects of adiponectin single nucleotide polymorphisms on the clustering of metabolic risk factors in young Korean adults
[PMID 21637951] A common variant in the adiponectin gene and polycystic ovary syndrome risk
[PMID 21726267] A Meta-analysis on the Association of Adiponectin Gene Polymorphisms with Coronary Heart Disease in Chinese Han Population
[PMID 22459242] Association of ADIPOQ variants, total and high molecular weight adiponectin levels with coronary artery disease in diabetic and non-diabetic Brazilian subjects
[PMID 22673923] An Association Study of SNP + 45 T > G of the AdipoQ Gene with Type 2 Diabetes in Yi and Han People in China
[PMID 22714914] Common polymorphisms (rs2241766 and rs1501299) in the ADIPOQ gene are not associated with hypertension susceptibility among the Chinese
[PMID 15616038] Linkage of plasma adiponectin levels to 3q27 explained by association with variation in the APM1 gene.
[PMID 16990411] Association of adiponectin gene variations with risk of incident myocardial infarction and ischemic stroke: a nested case-control study.
[PMID 17357083] Medical sequencing at the extremes of human body mass.
[PMID 17712123] Single nucleotide polymorphisms at the adiponectin locus and risk of coronary heart disease in men and women.
[PMID 18523726] Adiponectin gene ADIPOQ SNP associations with serum adiponectin in two female populations and effects of SNPs on promoter activity.
[PMID 18548168] Adiponectin and adiponectin receptor gene variants in relation to type 2 diabetes and insulin resistance-related phenotypes.
[PMID 18603647] Functional genetic polymorphisms and female reproductive disorders: Part I: Polycystic ovary syndrome and ovarian response.
[PMID 18716158] Adiponectin gene variants are associated with insulin sensitivity in response to dietary fat consumption in Caucasian men.
[PMID 18776141] Common variants in the adiponectin gene (ADIPOQ) associated with plasma adiponectin levels, type 2 diabetes, and diabetes-related quantitative traits: the Framingham Offspring Study.
[PMID 18827209] Variants of the adiponectin (ADIPOQ) and adiponectin receptor 1 (ADIPOR1) genes and colorectal cancer risk.
[PMID 19035456] Adipokine genes and prostate cancer risk.
[PMID 19037660] The association of SNPs in ADIPOQ, ADIPOR1, and ADIPOR2 with insulin sensitivity in a cohort of adolescents and their parents.
[PMID 19238139] ADIPOQ polymorphisms, monounsaturated fatty acids, and obesity risk: the GOLDN study.
[PMID 19661719] Interaction of ADIPOQ genetic polymorphism with blood pressure and plasma cholesterol level on the risk of coronary artery disease.
[PMID 19755407] Association of the +45T>G and +276G>T polymorphisms in the adiponectin gene with insulin resistance in nondiabetic Greek women.
[PMID 19912668] Design and evaluation of a treatment programme for Spanish adolescents with overweight and obesity. The EVASYON Study.
[PMID 20201642] Associations of polymorphisms in adiponectin and leptin genes with men's longevity.
[PMID 20230294] Analysis of adiponectin gene polymorphisms in dilated cardiomyopathy in a Han Chinese population.
[PMID 20848215] Association of adiponectin gene polymorphisms with the risk of ischemic stroke in a Chinese Han population.
[PMID 21054480] Genetic effects of adiponectin on blood lipids and blood pressure.
[PMID 21219602] Association of ADIPOQ gene variants with body weight, type 2 diabetes and serum adiponectin concentrations: the Finnish Diabetes Prevention Study.
[PMID 21623778] Adiponectin in chronic heart failure: influence of diabetes and genetic variants.
[PMID 21638131] Associations between single-nucleotide polymorphisms (+45T>G, +276G>T, -11377C>G, -11391G>A) of adiponectin gene and type 2 diabetes mellitus: a systematic review and meta-analysis.
[PMID 22070425] Profile of inflammatory mediators in gestational diabetes mellitus: phenotype and genotype.
[PMID 22386722] Association of ADIPOQ gene polymorphisms and coronary artery disease risk: a meta-analysis based on 12 465 subjects.
[PMID 22391941] Meta-analysis of association studies between five candidate genes and type 2 diabetes in Chinese Han population.
[PMID 22583123] Association of TCF7L2 and ADIPOQ with Body Mass Index, Waist-Hip Ratio, and Systolic Blood Pressure in an Endogamous Ethnic Group of India.
[PMID 23041095] Genetic variability on adiponectin gene affects myocardial infarction risk: The role of endothelial dysfunction
[PMID 23118546] Association of ADIPOQ +45T>G polymorphism with body fat mass and blood levels of soluble adiponectin and inflammation markers in a Mexican-Mestizo population
[PMID 23143890] Adiponectin (ADIPOQ) rs2241766 G/T polymorphism is associated with risk of cancer: evidence from a meta-analysis
[PMID 23151860] +276 G/T single nucleotide polymorphism of the adiponectin gene is associated with the susceptibility to biliary atresia
[PMID 23200411] ADIPOQ gene polymorphisms and cancer risk: A meta-analysis
[PMID 23370338] Adiponectin gene polymorphisms may not be associated with idiopathic premature ovarian failure
[PMID 23653335] AdipoQ polymorphisms are associated with type 2 diabetes mellitus: a meta-analysis study
[PMID 23658423] Adiponectin Gene Variant Interacts with Fish Oil Supplementation to Influence Serum Adiponectin in Older Individuals
[PMID 23740135] The adiponectin gene single-nucleotide polymorphism rs1501299 is associated with hepatocellular carcinoma risk
[PMID 23803590] Polymorphisms of the adiponectin gene in gestational hypertension and pre-eclampsia
[PMID 23260797] Variants of the adiponectin gene and diabetic microvascular complications in patients with type 2 diabetes
[PMID 23805506] [Association of adiponectin gene polymorphrism with metabolic syndrome in older Han adults from major cities in China]
[PMID 23819115] Association of Atherosclerotic Peripheral Arterial Disease with Adiponectin Genes SNP+45 and SNP+276: A Case-Control Study
[PMID 23826253] Gene Polymorphisms of ADIPOQ +45T>G, UCP2 -866G>A, and FABP2 Ala54Thr on the Risk of Colorectal Cancer: A Matched Case-Control Study
[PMID 23972466] Association Between the Adiponectin +45T>G Genotype and Risk of Cardiovascular Disease: A Meta-analysis
[PMID 24293390] An updated meta-analysis of the association between ADIPOQ rs2241766 polymorphism and colorectal cancer
[PMID 24559720] Family-based analysis of adiponectin gene polymorphisms in Chinese Han polycystic ovary syndrome
[PMID 23065236] The roles of ADIPOQ genetic variations in cancer risk: evidence from published studies.
[PMID 23144319] Prognostic implications of genetic variants in advanced non-small cell lung cancer: a genome-wide association study.
[PMID 23144325] P2X7-regulated protection from exacerbations and loss of control is independent of asthma maintenance therapy.
[PMID 23552441] Association of adiponectin gene polymorphism with birth weight in Korean neonates.
[PMID 24894086] Adiponectin gene (ADIPOQ) polymorphisms correlate with the progression of nephropathy in Taiwanese male patients with type 2 diabetes
[PMID 25074391] Correlation of serum adiponectin and adiponectin gene polymorphism with metabolic syndrome in Chinese adolescents
[PMID 25135112] Assessment of type 2 diabetes risk conferred by SNPs rs2241766 and rs1501299 in the ADIPOQ gene, a case/control study combined with meta-analyses
[PMID 25223469] Association of ADIPOQ polymorphisms with obesity risk: A meta-analysis
[PMID 26329379] Adiponectin Gene Polymorphisms are Associated with Increased Risk of Colorectal Cancer
[PMID 26546898] Plasma Adiponectin Concentrations and Adiponectin Gene Polymorphisms Are Associated with Bronchial Asthma in the Chinese Li Population
[PMID 26884098] Single Nucleotide Polymorphism (SNP) in the Adiponectin Gene and Cardiovascular Disease.
[PMID 26887769] [Case-control based study between polymorphisms in the adiponectin gene and polycystic ovary syndrome].
[PMID 27159547] Adipokine Gene Single-Nucleotide Polymorphisms in Portuguese Obese Adolescents: Associations with Plasma Concentrations of Adiponectin, Resistin, IL-6, IL-1β, and TNF-α.
[PMID 28737466] Association of AdipoQ single-nucleotide polymorphisms and smoking interaction with the risk of coronary heart disease in Chinese Han population.