|(C;T)||1.2||1.2x increased risk for diabetic nephropathy in some populations|
|(T;T)||1.4||1.4x increased risk for diabetic nephropathy in some populations|
- rs2237897, P = 6.8 times 10-13; OR = 1.41, 95% CI = 1.29â€“1.55)
A study of 754 type-2 diabetes patients plus a meta-analysis concluded that rs2237897(T) was significantly associated with susceptibility to diabetic nephropathy in T2D Japanese subjects (odds ratio = 1.22, CI: 1.10-1.34, corrected p = 0.01).[PMID 20056949]
[PMID 19366866] Association of type 2 diabetes candidate polymorphisms in KCNQ1 with incretin and insulin secretion
|Trait||Type 2 diabetes|
|Title||SNPs in KCNQ1 are associated with susceptibility to type 2 diabetes in East Asian and European populations|
|Odds Ratio||1.33 [1.24-1.41]|
[PMID 19448982] Variants in KCNQ1 are associated with susceptibility to type 2 diabetes in the population of mainland China
[PMID 19516902] The type 2 diabetes associated minor allele of rs2237895 KCNQ1 associates with reduced insulin release following an oral glucose load
[PMID 19575309] Association study of four variants in KCNQ1 with type 2 diabetes mellitus and premature coronary artery disease in a Chinese population
[PMID 19308350] Variations in KCNQ1 are associated with type 2 diabetes and beta cell function in a Chinese population
[PMID 19252135] Genetic variation in KCNQ1 associates with fasting glucose and beta-cell function: a study of 3,734 subjects comprising three ethnicities living in Singapore.
[PMID 19556355] Common variants in KCNQ1 are associated with type 2 diabetes and impaired fasting glucose in a Chinese Han population.
[PMID 20174558] A genome-wide association study identifies susceptibility variants for type 2 diabetes in Han Chinese.
[PMID 20701788] KCNQ1 gene polymorphisms are associated with lipid parameters in a Chinese Han population.
[PMID 21261977] Variants in KCNQ1 increase type II diabetes susceptibility in South Asians: a study of 3,310 subjects from India and the US.
[PMID 21289621] Effects of KCNQ1 polymorphisms on the therapeutic efficacy of oral antidiabetic drugs in Chinese patients with type 2 diabetes.
[PMID 21767287] Replication of genome-wide association signals of type 2 diabetes in Han Chinese in a prospective cohort.
[PMID 22696034] KCNQ1 SNPS and susceptibility to diabetic nephropathy in East Asians with type 2 diabetes.
|qualified_impact||Insufficiently evaluated pathogenic|
[PMID 23271129] Meta-analysis of the effect of KCNQ1 gene polymorphism on the risk of type 2 diabetes
[PMID 23786590] Common Variants in KCNQ1 Confer Increased Risk of Type 2 Diabetes and Contribute to the Diabetic Epidemic in East Asians: A Replication and Meta-Analysis
[PMID 23298195] Association study of genetic variants of 17 diabetes-related genes/loci and cardiovascular risk and diabetic nephropathy in the Chinese She population.
[PMID 23544998] Association of TRPC1 gene polymorphisms with type 2 diabetes and diabetic nephropathy in Han Chinese population.
|Trait||Type 2 diabetes|
|Title||Sequence variants in SLC16A11 are a common risk factor for type 2 diabetes in Mexico.|
|Odds Ratio||1.31 [1.22-1.41]|
[PMID 25749274] Joint effect of CENTD2 and KCNQ1 polymorphisms on the risk of type 2 diabetes mellitus among chinese han population