|(A;G)||2.1||~1.5-3x increased risk for ischemic stroke|
|(G;G)||2.2||~1.5-3x increased risk for ischemic stroke|
In a study of incident ischemic stroke during 14 years of follow-up in a population-based study of older adults known as the Cardiovascular Health Study (CHS), rs2231137 was associated with stroke in both white (hazard ratio, 1.46, CI: 1.05 - 2.03) and black (hazard ratio, 3.59, CI, 1.11 - 11.6) participants. The risk of ischemic stroke was higher in Val allele homozygotes than in Met allele carriers. The adjusted hazard ratio for Val allele homozygotes, compared with Met allele carriers, was 1.50 (90% CI, 1.06 to 2.12) in whites and 3.62 (90% CI, 1.11 to 11.9) in black participants (Table 4). [PMID 19023099]
[PMID 21311724] Genetic polymorphisms of ATP-binding cassette (ABC) proteins, overall survival and drug toxicity in patients with Acute Myeloid Leukemia
[PMID 18547414] Genotyping panel for assessing response to cancer chemotherapy.
[PMID 19584153] Clinical relevance of a pharmacogenetic approach using multiple candidate genes to predict response and resistance to imatinib therapy in chronic myeloid leukemia.
[PMID 20389299] Pazopanib-induced hyperbilirubinemia is associated with Gilbert's syndrome UGT1A1 polymorphism.
|qualified_impact||Insufficiently evaluated pharmacogenetic|
|Disease||Uric acid concentration Blood group|
|CLNDBN||Uric acid concentration, serum, quantitative trait locus 1 Blood group, Junior system|
|CLNSRC||OMIM Allelic Variant UniProtKB (protein)|
[PMID 26109419] Polymorphisms in ATP-binding cassette transporter genes and interaction with diet and life style factors in relation to colorectal cancer in a Danish prospective case-cohort study