rs2144908
| Orientation | plus |
| Stabilized | plus |
| Geno | Mag | Summary |
|---|---|---|
| (G;A) |
| Make rs2144908(A;A) |
| Make rs2144908(A;G) |
| Make rs2144908(G;G) |
| Reference | GRCh38 38.1/141 |
| Chromosome | 20 |
| Position | 44357077 |
| Gene | HNF4A, LOC105372629 |
| is a | snp |
| is | mentioned by |
| dbSNP | rs2144908 |
| dbSNP (classic) | rs2144908 |
| ClinGen | rs2144908 |
| ebi | rs2144908 |
| HLI | rs2144908 |
| Exac | rs2144908 |
| Gnomad | rs2144908 |
| Varsome | rs2144908 |
| LitVar | rs2144908 |
| Map | rs2144908 |
| PheGenI | rs2144908 |
| Biobank | rs2144908 |
| 1000 genomes | rs2144908 |
| hgdp | rs2144908 |
| ensembl | rs2144908 |
| geneview | rs2144908 |
| scholar | rs2144908 |
| rs2144908 | |
| pharmgkb | rs2144908 |
| gwascentral | rs2144908 |
| openSNP | rs2144908 |
| 23andMe | rs2144908 |
| SNPshot | rs2144908 |
| SNPdbe | rs2144908 |
| MSV3d | rs2144908 |
| GWAS Ctlg | rs2144908 |
| GMAF | 0.2493 |
| Max Magnitude | 0 |
| ? | (A;A) (A;G) (G;G) | 28 |
|---|---|---|
|
| ||
Affects type-2 diabetes
[PMID 15047633] [PMID 15504983] [PMID 15735892] [PMID 16522129] [PMID 16522130] [PMID 16523192] [PMID 16523193] [PMID 16523194] [PMID 16752173]
[PMID 21544032] Genetic and clinical risk factors of new-onset diabetes after transplantation in Hispanic kidney transplant recipients
[PMID 21633728] Hepatocyte nuclear factor 4 alpha P2 promoter variants associate with insulin resistance
[PMID 21983932] Association of Hepatocyte Nuclear Factor 4 Alpha Polymorphisms with Type 2 Diabetes With or Without Metabolic Syndrome in Malaysia
[PMID 16186411
] Variants in hepatocyte nuclear factor 4alpha are modestly associated with type 2 diabetes in Pima Indians.
[PMID 16838170] Single nucleotide polymorphisms of the HNF4alpha gene are associated with the conversion to type 2 diabetes mellitus: the STOP-NIDDM trial.
[PMID 17805472] Association of genetic variations near P2 promoter of the hepatocyte nuclear factor-4alpha gene and insulin secretion index in Thais.
[PMID 17827402] Studies in 3,523 Norwegians and meta-analysis in 11,571 subjects indicate that variants in the hepatocyte nuclear factor 4 alpha (HNF4A) P2 region are associated with type 2 diabetes in Scandinavians.
[PMID 17894829] Gene-gene interactions between HNF4A and KCNJ11 in predicting Type 2 diabetes in women.
[PMID 18162503] Evidence of interaction between PPARG2 and HNF4A contributing to variation in insulin sensitivity in Mexican Americans.
[PMID 18332101] Common variants in maturity-onset diabetes of the young genes and future risk of type 2 diabetes.
[PMID 18340007] Association of stearoyl-CoA desaturase 1 activity with familial combined hyperlipidemia.
[PMID 18498634] The genetic susceptibility to type 2 diabetes may be modulated by obesity status: implications for association studies.
[PMID 18654034] A common P2 promoter polymorphism of the hepatocyte nuclear factor-4alpha gene is associated with insulin secretion in non-obese Japanese with type 2 diabetes.
[PMID 18728231] Population-specific risk of type 2 diabetes conferred by HNF4A P2 promoter variants: a lesson for replication studies.
[PMID 19915572] Genome-wide association study of ulcerative colitis identifies three new susceptibility loci, including the HNF4A region.
[PMID 20079163] Effect of genetic variants in KCNJ11, ABCC8, PPARG and HNF4A loci on the susceptibility of type 2 diabetes in Chinese Han population.
[PMID 20361036] Gene-gene interactions lead to higher risk for development of type 2 diabetes in an Ashkenazi Jewish population.
[PMID 21062274] Association of novel variants in the hepatocyte nuclear factor 4A gene with maturity onset diabetes of the young and early onset type 2 diabetes.
[PMID 30415809] Hepatocyte Nuclear Factor-4α P2 Promoter Variants Are Associated With the Risk of Metabolic Syndrome and Testosterone Deficiency in Aging Taiwanese Men.
