| Geno
|
Mag
|
Summary
|
| (G;G)
|
0
|
|
| (G;T)
|
1.2
|
1.2x increased risk for ovarian cancer
|
| (T;T)
|
1.4
|
1.4x increased risk for ovarian cancer
|
rs2072590 is a SNP on chromosome 2q31, in a noncoding region ~5 kb distal to the HOXD3 gene and ~10 kb proximal to HOXD1.
A genome-wide association study ultimately including over 10,000 ovarian cancer patients found statistically strong (p = 3.8 × 10e?14) evidence for slightly elevated risk associated with the rs2072590(T) allele, with an odds ratio of 1.20 (CI: 1.14–1.25) as calculated for the serous subtype (of ovarian cancer), though it was significant for the other subtypes as well.[PMID 20852632
]
| GWAS snp
|
| PMID
|
[PMID 20852632]
|
| Trait
|
|
| Title
|
A genome-wide association study identifies susceptibility loci for ovarian cancer at 2q31 and 8q24
|
| Risk Allele
|
T
|
| P-val
|
5E-14
|
| Odds Ratio
|
1.16 [1.12-1.21]
|
[PMID 22235027] Evaluation of microRNA expression profiles and their associations with risk alleles in lymphoblastoid cell lines of familial ovarian cancer.
| GWAS snp
|
| PMID
|
[PMID 23535730]
|
| Trait
|
Ovarian cancer
|
| Title
|
GWAS meta-analysis and replication identifies three new susceptibility loci for ovarian cancer.
|
| Risk Allele
|
|
| P-val
|
3E-10
|
| Odds Ratio
|
1.13 [1.09-1.18]
|
[PMID 23133607] Associations between gene expression variations and ovarian cancer risk alleles identified from genome wide association studies.
[PMID 25173882] Replication Study for the Association of Seven Genome- Gwas-Identified Loci With Susceptibility to Ovarian Cancer in the Polish Population
[PMID 29262571] Ovarian cancer variant rs2072590 is associated with HOXD1 and HOXD3 gene expression.
]
