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rs2059693

From SNPedia

Orientationplus
Stabilizedplus
Geno Mag Summary
(C;C) 0 normal
(C;T) 1.3 1.3x increased risk for testicular cancer
(T;T) 1.6 1.6x increased risk for testicular cancer
ReferenceGRCh38 38.1/141
Chromosome2
Position219577768
GeneINHA
is asnp
is mentioned by
dbSNPrs2059693
ClinGenrs2059693
ebirs2059693
HLIrs2059693
Exacrs2059693
Varsomers2059693
Maprs2059693
PheGenIrs2059693
hapmaprs2059693
1000 genomesrs2059693
hgdprs2059693
ensemblrs2059693
gopubmedrs2059693
geneviewrs2059693
scholarrs2059693
googlers2059693
pharmgkbrs2059693
gwascentralrs2059693
openSNPrs2059693
23andMers2059693
23andMe allrs2059693
SNP Nexus

SNPshotrs2059693
SNPdbers2059693
MSV3drs2059693
GWAS Ctlgrs2059693
GMAF0.309
Max Magnitude1.6
? (C;C) (C;T) (T;T) 28
A study of 577 cases of testicular germ cell tumors, the most common testicular cancer in young men, concluded that the rs2059693(T) allele increased risk. Among Caucasians, the odds ratio for the rs2059693(C;T) genotype was 1.33 (CI: 1.04-1.71), and for the (T;T) genotype, 1.60 (CI: 1.01-2.52, p(trend) = 0.008). The association with rs2059693 was even stronger for nonseminomas, and for teratomas and teratocarcinomas in particular (N = 58; (C;T) odds ratio 1.63, CI: 0.89-2.99; (T;T) odds ratio 4.54, CI: 2.00-10.3, p(trend) = 0.0008).[PMID 18413775OA-icon.png]