|?|| (A;A) (A;C) (C;C) ||28|
Carriers of an 228Ala allele for rs20576
who have prostate cancer
and are treated by radiation therapy have a higher risk (odds ratio 2.47, CI: 1.10-5.54, p=0.028) for subsequent metastasis. [PMID 18163425
[PMID 19643596] TRAIL-R1 polymorphisms and cancer susceptibility: An evidence-based meta-analysis
[PMID 21484799] Association of death receptor 4 variant (683A > C) with ovarian cancer risk in BRCA1 mutation carriers.
|| not reviewed
|| Insufficiently evaluated not reviewed
[PMID 23658636] Candidate Gene Study of TRAIL and TRAIL Receptors: Association with Response to Interferon Beta Therapy in Multiple Sclerosis Patients
[PMID 24587306] Death Receptor (DR4) Haplotypes Are Associated with Increased Susceptibility of Gallbladder Carcinoma in North Indian Population
[PMID 25207117] A Study of the Impact of Death Receptor 4 (DR4) Gene Polymorphisms in Alzheimer's Disease
[PMID 28975649] Evaluation of TRAIL receptor 1 (DR4) Polymorphisms C626G and A683C as risk factors of hepatocellular carcinoma.