rs1992660
From SNPedia
| Orientation | minus |
| Stabilized | minus |
| Geno | Mag | Summary |
|---|---|---|
| (A;A) | increased risk for Crohn's disease | |
| (A;G) | ? | |
| (G;G) | 0.72x decreased risk for Crohn's disease |
| Reference | GRCh38 38.1/141 |
| Chromosome | 5 |
| Position | 40414965 |
| Gene | PTGER4 |
| is a | snp |
| is | mentioned by |
| dbSNP | rs1992660 |
| dbSNP (classic) | rs1992660 |
| ClinGen | rs1992660 |
| ebi | rs1992660 |
| HLI | rs1992660 |
| Exac | rs1992660 |
| Gnomad | rs1992660 |
| Varsome | rs1992660 |
| LitVar | rs1992660 |
| Map | rs1992660 |
| PheGenI | rs1992660 |
| Biobank | rs1992660 |
| 1000 genomes | rs1992660 |
| hgdp | rs1992660 |
| ensembl | rs1992660 |
| geneview | rs1992660 |
| scholar | rs1992660 |
| rs1992660 | |
| pharmgkb | rs1992660 |
| gwascentral | rs1992660 |
| openSNP | rs1992660 |
| 23andMe | rs1992660 |
| SNPshot | rs1992660 |
| SNPdbe | rs1992660 |
| MSV3d | rs1992660 |
| GWAS Ctlg | rs1992660 |
| GMAF | 0.4619 |
| Max Magnitude | 0 |
| ? | (A;A) (A;G) (G;G) | 28 |
|---|---|---|
|
| ||
rs1992660 is a SNP upstream of the PTGER4 gene that was found in a genome-wide association study to be associated with Crohn's disease.
In several European populations, the most common allele, rs1992660(A), was associated with increased risk for Crohn's disease. Conversely, the odds ratio (pooled over several populations) for the minor allele, rs1992660(G), was 0.72 (CI: 0.60-0.86, p=0.0005).[PMID 17684544
]
| GWAS | |
|---|---|
| SNP | rs1992660 |
| PubMedID | [PMID 17684544]
|
| Condition | Irritable bowel syndrome |
| Gene | PTGER4 |
| Risk Allele | |
| pValue | 4.00E-007 |
| OR | 1.42 |
| 95% CI | 1.24-1.67 |
