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rs1937506

From SNPedia

Orientationplus
Stabilizedplus
Geno Mag Summary
(A;A) 0 1.6x risk
(A;G) 1.3x risk
(G;G) normal
ReferenceGRCh38 38.1/141
Chromosome13
Position67461239
is asnp
is mentioned by
dbSNPrs1937506
dbSNP (old)rs1937506
ClinGenrs1937506
ebirs1937506
HLIrs1937506
Exacrs1937506
Varsomers1937506
Maprs1937506
PheGenIrs1937506
Biobankrs1937506
1000 genomesrs1937506
hgdprs1937506
ensemblrs1937506
gopubmedrs1937506
geneviewrs1937506
scholarrs1937506
googlers1937506
pharmgkbrs1937506
gwascentralrs1937506
openSNPrs1937506
23andMers1937506
23andMe allrs1937506
SNP Nexus

SNPshotrs1937506
SNPdbers1937506
MSV3drs1937506
GWAS Ctlgrs1937506
GMAF0.2236
Max Magnitude0
? (A;A) (A;G) (G;G) 28
rs1937506 has been reported in a large study to be associated with high blood pressure.

The risk allele (oriented to the dbSNP entry) is (G); the odds ratio associated with heterozygotes is 1.33 (CI 1.04-1.69), and for homozygotes, 1.60 (CI 1.26-2.02). [PMID 17554300OA-icon.png]

As follows from results of Replication of the Wellcome Trust genome-wide association study of essential hypertension this SNP (rs1937506) only one of the top 6 SNPs which might be associated with essential hypertension in Americans of European origin. This SNP shows a significant but opposite effect in Americans of Hispanic origin. Each additional G allele of rs1937506 is associated with a 24.9 mmHg decrease of systolic blood pressure (SBP) in European Americans and with a 27.7 mmHg increase in Hispanic Americans. Considering diastolic blood pressure (DBP) each additional G allele is associated with a 8.7 mmHg decrease of DBP in European Americans, whereas the results are non-significant for Hispanic Americans. [PMID: 18523456]

[PMID 19439027OA-icon.png] Dissecting complex traits: recent advances in hypertension genomics.

[PMID 21228780] Novel genetic variations associated with salt sensitivity in the Korean population.