|(G;G)||2.3||1.28x increased risk for prostate cancer|
|?||(G;G) (G;T) (T;T)||28|
rs1859962 is a SNP on chromosome 17q24.3, associated with increased risk for prostate cancer in several studies.
In a study of over 3,600 Caucasians with prostate cancer, rs1859962 is one of five SNPs used (with family history as a sixth factor) to cumulatively predict overall risk. On its own, the rs1859962(G;G) risk genotype yields an odds ratio for developing prostate cancer of 1.28 (CI: 1.11-1.47, p=5.5x10e-4) and may account for 6.5% of population attributable risk.10.1056/NEJMoa075819
news linked to Prostate cancer and type-2 diabetes
cancer-genetics these snps influence genetic risk for prostate cancer
- the haplotype rs6983267 rs1016343 rs4242384
|Title||Multiple newly identified loci associated with prostate cancer susceptibility|
|Odds Ratio||1.26 [NR]|
|Title||Identification of seven new prostate cancer susceptibility loci through a genome-wide association study|
|Odds Ratio||NR NR|
[PMID 21086507] GWAS SNP Replication among African American and European American men in the North Carolina-Louisiana prostate cancer project (PCaP)
|Title||Genome-wide association study identifies new prostate cancer susceptibility loci.|
|Odds Ratio||1.2700 [1.18-1.37]|
[PMID 21959049] Association between single nucleotide polymorphisms on chromosome 17q and the risk of prostate cancer in a Chinese population
[PMID 22665440] Integrative functional genomics identifies an enhancer looping to the SOX9 gene disrupted by the 17q24.3 prostate cancer risk locus
[PMID 18491292] Cumulative effect of five genetic variants on prostate cancer risk in multiple study populations.
[PMID 18701471] Chromosome 17q12 variants contribute to risk of early-onset prostate cancer.
[PMID 18794092] Association of prostate cancer risk variants with clinicopathologic characteristics of the disease.
[PMID 18974127] Association study of prostate cancer susceptibility variants with risks of invasive ovarian, breast, and colorectal cancer.
[PMID 19058137] Clinical utility of five genetic variants for predicting prostate cancer risk and mortality.
[PMID 19104501] Prostate cancer genomics: towards a new understanding.
[PMID 19318432] Generalizability of associations from prostate cancer genome-wide association studies in multiple populations.
[PMID 19366828] Evaluation of 8q24 and 17q risk loci and prostate cancer mortality.
[PMID 19371897] Pathological outcomes associated with the 17q prostate cancer risk variants.
[PMID 19434657] Individual and cumulative effect of prostate cancer risk-associated variants on clinicopathologic variables in 5,895 prostate cancer patients.
[PMID 19549807] Prostate cancer risk associated loci in African Americans.
[PMID 19727433] Cancer genetic association studies in the genome-wide age.
[PMID 20026053] WITHDRAWN: Relationships between 8q24 and 17q risk loci and sporadic or latent prostate cancer and the impacts of these loci on the clinicopathologic characteristics of prostate cancer.
[PMID 20039378] Estimation of genotype relative risks from pedigree data by retrospective likelihoods.
[PMID 20690139] Meta-analysis of genome-wide and replication association studies on prostate cancer.
[PMID 21390317] Characterizing associations and SNP-environment interactions for GWAS-identified prostate cancer risk markers--results from BPC3.
[PMID 21456070] GWAS SNP Replication among African American and European American men in the North Carolina-Louisiana prostate cancer project (PCaP).
[PMID 21538423] Early onset prostate cancer has a significant genetic component.
[PMID 21557267] A replication study examining three common single-nucleotide polymorphisms and the risk of prostate cancer in a Japanese population.
[PMID 22077888] Association of prostate cancer risk alleles with unfavourable pathological characteristics in potential candidates for active surveillance.
[PMID 22561070] 8q24 and 17q Prostate cancer susceptibility loci in a multiethnic Asian cohort().
[PMID 24037955] The presence of prostate cancer at biopsy is predicted by a number of genetic variants