rs180177133

Orientation

minus

Stabilized

minus

Geno	Mag	Summary
(-;-)	7	Fanconi anemia, complementation group N
(-;A)	3	increased risk of breast cancer
(A;A)	0	common in clinvar

Reference

GRCh38 38.1/141

Chromosome

16

Position

23614089

Gene

PALB2

is a	snp
is	mentioned by
dbSNP	rs180177133
dbSNP (classic)	rs180177133
ClinGen	rs180177133
ebi	rs180177133
HLI	rs180177133
Exac	rs180177133
Gnomad	rs180177133
Varsome	rs180177133
LitVar	rs180177133
Map	rs180177133
PheGenI	rs180177133
Biobank	rs180177133
1000 genomes	rs180177133
hgdp	rs180177133
ensembl	rs180177133
geneview	rs180177133
scholar	rs180177133
google	rs180177133
pharmgkb	rs180177133
gwascentral	rs180177133
openSNP	rs180177133
23andMe	rs180177133
SNPshot	rs180177133
SNPdbe	rs180177133
MSV3d	rs180177133
GWAS Ctlg	rs180177133

Max Magnitude

7

ClinVar
Risk	Rs180177133(-;-)
Alt	Rs180177133(-;-)
Reference	Rs180177133(A;A)
Significance	Other
Disease	Breast cancer Familial cancer of breast Fanconi anemia Pancreatic cancer 3 Hereditary cancer-predisposing syndrome not provided
Variation	info
Gene	PALB2
CLNDBN	Breast cancer, susceptibility to Familial cancer of breast Fanconi anemia, complementation group N Pancreatic cancer 3 Hereditary cancer-predisposing syndrome not provided
Reversed	1
HGVS	NC_000016.9:g.23625410delT
CLNSRC	OMIM Allelic Variant PALB2 database
CLNACC	RCV000001309.2, RCV000114595.4, RCV000114596.2, RCV000114597.3, RCV000131150.4, RCV000235691.2,

[PMID 17200668] PALB2, which encodes a BRCA2-interacting protein, is a breast cancer susceptibility gene.

[PMID 18302019] Analysis of FANCB and FANCN/PALB2 fanconi anemia genes in BRCA1/2-negative Spanish breast cancer families.