|(T;T)||increased waist circumference and risk of disk disease|
|On GW 5.0||0|
|Odds Ratio Het||1.31|
|Odds Ratio Hom||7.87|
|Odds Ratio All|
|Disease||Intervertebral disc disease (IDD)|
A study of 556 adults in the Western Australian coronary heart disease (CHD) population concluded that rs1800587(T;T) homozygotes had larger waist circumference, by 1.8cm on average, compared to major allele (C;C) homozygotes. This association was even more pronounced in patients with higher levels of obesity or inflammatory markers. [PMID 18716798]
This SNP has also been reported to be associated with Alzheimer's disease in a few studies, but probably ruled out in even more studies, such as this one [PMID 19158434].
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[PMID 21637534] Interleukin-8-251T > A, Interleukin-1?-889C > T and Apolipoprotein E polymorphisms in Alzheimer's disease
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[PMID 16617143] Algorithm for automatic genotype calling of single nucleotide polymorphisms using the full course of TaqMan real-time data.
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[PMID 17459217] [A meta-analysis on interleukin-1 gene cluster polymorphism and genetic susceptibility for ankylosing spondylitis].
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[PMID 18633131] Host immune gene polymorphisms in combination with clinical and demographic factors predict late survival in diffuse large B-cell lymphoma patients in the pre-rituximab era.
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[PMID 19035492] Cytokine gene polymorphisms as risk and severity factors for juvenile dermatomyositis.
[PMID 19043479] Association of -31T>C and -511 C>T polymorphisms in the interleukin 1 beta (IL1B) promoter in Korean keratoconus patients.
[PMID 19066394] Organochlorine exposure, immune gene variation, and risk of non-Hodgkin lymphoma.
[PMID 19131662] A meta-analysis of candidate gene polymorphisms and ischemic stroke in 6 study populations: association of lymphotoxin-alpha in nonhypertensive patients.
[PMID 19155622] Interleukin-1alpha -889 C/T polymorphism in Turkish patients with late-onset Alzheimer's disease.
[PMID 19263529] Genetic risk factors in recurrent venous thromboembolism: A multilocus, population-based, prospective approach.
[PMID 19330901] Association of 77 polymorphisms in 52 candidate genes with blood pressure progression and incident hypertension: the Women's Genome Health Study.
[PMID 19559392] A candidate gene association study of 77 polymorphisms in migraine.
[PMID 19742166] Epistasis between IL1A, IL1B, TNF, HTR2A, 5-HTTLPR and TPH2 variations does not impact alcohol dependence disorder features.
[PMID 20031567] An evaluation of candidate genes of inflammation and thrombosis in relation to the risk of venous thromboembolism: The Women's Genome Health Study.
[PMID 20192980] The interleukin-1 cluster gene region is associated with multiple sclerosis in an Italian Caucasian population.
[PMID 20196868] Polymorphisms in IL-1beta, vitamin D receptor Fok1, and Toll-like receptor 2 are associated with extrapulmonary tuberculosis.
[PMID 20347268] Convergent evidence shows a positive association of interleukin-1 gene complex locus with susceptibility to schizophrenia in the Caucasian population.
[PMID 20353565] Allelic variants of IL1R1 gene associate with severe hand osteoarthritis.
[PMID 20574532] Intermediate phenotypes identify divergent pathways to Alzheimer's disease.
[PMID 20811626] Genetic variants in inflammation-related genes are associated with radiation-induced toxicity following treatment for non-small cell lung cancer.
[PMID 20934174] Association of IL1 gene polymorphisms with chronic periodontitis in Brazilians.
[PMID 21205020] Associations between interleukin-1 (IL-1) gene variations or IL-1 receptor antagonist levels and the development of type 2 diabetes.
[PMID 21385326] Association of interleukin-1 gene polymorphisms with sudden sensorineural hearing loss and Meniere's disease.
[PMID 22035161] Postorthodontic external root resorption is associated with IL1 receptor antagonist gene variations.
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[PMID 23050050] Gender difference in genetic association between IL1A variant and early lumbar disc degeneration: a three-year follow-up
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[PMID 24103372] Interleukin-1 alpha (rs1800587) genetic polymorphism is associated with specific cognitive functions but not depression or loneliness in elderly males without dementia
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[PMID 22623017] Serotonin transporter-linked polymorphic region (5-HTTLPR) genotype is associated with cortisol responsivity to naloxone challenge.
[PMID 22925444] Genetic and immunological markers predict titanium implant failure: a retrospective study.
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[PMID 23594042] Multiple sclerosis: association with the interleukin-1 gene family polymorphisms in the Turkish population.
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