This rare genotype causes hereditary hemochromatosis. This can result in serious iron overload in males or post-menopausal females, but is easily treated.
This ACMG report recommends 4 clinical actions for those carrying two C282Y copies:
- Serum ferritin concentrations should be measured to establish disease status and prognosis.
- MRI to estimate parenchymal iron content, including the liver and possibly the heart
- When serum ferritin and liver enzyme levels are abnormal, liver biopsy can establish or exclude cirrhosis.
- Consultation with a medical geneticist and/or genetic counselor.
comments at this reddit thread may be useful