|?|| (C;C) (C;G) (G;G) ||28|
, located in the coding region of the GIPR
gene and known as Glu354Gln, shows a marginal association with cardiovascular disease (CVD) in a study of ~200 patients from a Dutch population. Heterozygotes are reported to be at lower risk for CVD, with an odds ratio of 0.72 (CI: 0.52 - 0.97, p=0.03). However, no significant association was seen for homozygous carriers of the minor allele. [PMID 17624916
[PMID 19254363] Gastric inhibitory polypeptide receptor: association analyses for obesity of several polymorphisms in large study groups.
[PMID 20081857] Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge.
[PMID 20516203] Association of variants in gastric inhibitory polypeptide receptor gene with impaired glucose homeostasis in obese children and adolescents from Berlin.
|| not reviewed
|| Insufficiently evaluated not reviewed
|| [PMID 23563607]
|| Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture.
| Risk Allele
| Odds Ratio
|| 1.10 [NR]
[PMID 24446656] A Functional Amino Acid Substitution in the Glucose-dependent Insulinotropic Polypeptide-Receptor (GIPR) Gene is Associated with Lower Bone Mineral Density and Increased Fracture risk