|(-;-)||2||less favorable clinical outcome when on antipsychotics|
|(-;C)||2||1.3x increased adenoma recurrence risk|
In a study of individuals in the Polyp Prevention Trial with any, multiple (>/=2) or advanced colorectal adenoma recurrence after 4 years, compared to those without adenoma recurrence, rs1799732(C;T) individuals were significantly associated with all adenoma recurrence (odds ratio 1.30, CI: 1.01-1.69). The authors speculate this increased risk of adenoma recurrence (and an association with colorectal cancer) may be related to SNP-associated differences in alcohol and fat intake.[19065655?dopt=Abstract PMID 19065655]
23andMe blog Alcoholism related
[PMID 19373123] Genetic variants altering dopamine D2 receptor expression or function modulate the risk of opiate addiction and the dosage requirements of methadone substitution
[PMID 19547807] Association between the DRD2-141C Insertion/Deletion polymorphism and schizophrenia
[PMID 19512960] Genetic diagnostics of functional variants of the human dopamine D2 receptor gene
[PMID 20664489] DRD2 promoter region variation predicts antipsychotic-induced weight gain in first episode schizophrenia
[PMID 21714067] Association between polymorphisms of DRD2 and DRD4 and opioid dependence: Evidence from the current studies
[PMID 17135598] No evidence for a major role of polymorphisms during bupropion treatment.
[PMID 17417059] A dopamine D2 receptor gene-related polymorphism is associated with schizophrenia in a Spanish population isolate.
[PMID 17466074] Genetic polymorphisms in dopamine-related genes and smoking cessation in women: a prospective cohort study.
[PMID 18077373] Polymorphisms in human dopamine D2 receptor gene affect gene expression, splicing, and neuronal activity during working memory.
[PMID 18305461] Association between ADORA2A and DRD2 polymorphisms and caffeine-induced anxiety.
[PMID 18366720] Association of dopaminergic pathway gene polymorphisms with chronic renal insufficiency among Asian Indians with type-2 diabetes.
[PMID 18563706] The impact of genetic variation in DRD2 and SLC6A3 on smoking cessation in a cohort of participants 1 year after enrollment in a lung cancer screening study.
[PMID 18715757] Genetic associations with schizophrenia: meta-analyses of 12 candidate genes.
[PMID 19285111] C957T polymorphism of the human dopamine D2 receptor gene predicts extrastriatal dopamine receptor availability in vivo.
[PMID 19390575] Lung cancer susceptibility model based on age, family history and genetic variants.
[PMID 19669131] Clinical and pharmacogenetic determinants for the discontinuation of non-ergoline dopamine agonists in Parkinson's disease.
[PMID 20146828] Dopamine D2 receptor polymorphisms and susceptibility to alcohol dependence in Indian males: a preliminary study.
[PMID 20191112] The Genetics of Anorexia Nervosa: Current Findings and Future Perspectives.
[PMID 21162693] Pharmacogenetics and antipsychotics: therapeutic efficacy and side effects prediction.
[PMID 21554498] Dopaminergic genes modulate response inhibition in alcohol abusing adults.
[PMID 21645585] Resting posterior minus frontal EEG slow oscillations is associated with extraversion and DRD2 genotype.
[PMID 22382052] A DRD2 and ANKK1 haplotype is associated with nicotine dependence.
[PMID 22574669] Dopamine receptors D1 and D2 are related to observed maternal behavior.
[PMID 22615781] Candidate gene-based association study of antipsychotic-induced movement disorders in long-stay psychiatric patients: a prospective study
|qualified_impact||Insufficiently evaluated pharmacogenetic|
[PMID 22579533] Binge eating disorder and the dopamine D2 receptor: genotypes and sub-phenotypes.
[PMID 22875483] Identification of a novel ANKK1 and other dopaminergic (DRD2 and DBH) gene variants in migraine susceptibility.
[PMID 27121382] Incorporating epistasis interaction of genetic susceptibility single nucleotide polymorphisms in a lung cancer risk prediction model.