|(C;T)||2||if ApoE4(-), 1.6x risk of AD; if (+), 6.6x risk|
|(T;T)||2||if ApoE4(-), 1.6x risk of AD; if (+), 6.6x risk|
On its own, the rs1799724(T) allele led to an odds ratio of 1.63 (CI: 1.13-2.34, p=0.009). In carriers of ApoE4 alleles, the odds ratio changed from 2.92 (CI: 2.00-4.27) in the absence of rs1799724(T) to an OR of 6.65 (CI: 3.26-13.55, p=0.03) in its presence. [PMID 15895461] Note, however, that this study is from 2005 and it does not appear to have been independently replicated since then (which is why the magnitude is 2, i.e. pretty low on the 0-10 magnitude scale).
In a Chinese study [PMID 18551993], post-menopausal women were significantly more likely to have low bone mineral density if they had
- CC-AA genotypes in rs1799724-rs1800629
- a haplotype of rs1799724-rs1800629-rs6254-rs6256-IL-1ra-rs2227956-rs1801197
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|qualified_impact||Insufficiently evaluated pharmacogenetic|
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