| Geno
|
Mag
|
Summary
|
| (C;C)
|
|
highest phosphatidylcholine values
|
| (C;G)
|
|
intermediate phosphatidylcholine values
|
| (G;G)
|
|
lowest phosphatidylcholine values
|
FADS1 codes for an enzyme involved in fatty acid unsaturation and the FADS1 gene SNP rs174548 seems to explain as much as ten percent of the variance in the metabolism of some glycerophospholipids. news
A study of metabolite concentrations in the blood of 284 adult males from Southern Germany determined that several SNPs were associated either directly with a metabolite range or with a ratio of metabolites. The rarer rs174548(G) allele was associated with decreased phosphatidylcholine values. 10.1371/journal.pgen.1000282
| GWAS snp
|
| PMID
|
[PMID 19043545 ]
|
| Trait
|
Serum metabolites
|
| Title
|
Genetics Meets Metabolomics: A Genome-Wide Association Study of Metabolite Profiles in Human Serum
|
| Risk Allele
|
|
| P-val
|
5E-8
|
| Odds Ratio
|
NR NR
|
| GWAS snp
|
| PMID
|
[PMID 20864672]
|
| Trait
|
|
| Title
|
Genetic Variants Influencing Circulating Lipid Levels and Risk of Coronary Artery Disease
|
| Risk Allele
|
G
|
| P-val
|
1E-12
|
| Odds Ratio
|
0.01 [0.007-0.015] unit decrease
|
[PMID 22960237] Bivariate genome-wide association study suggests fatty acid desaturase genes and cadherin DCHS2 for variation of both compressive strength index and appendicular lean mass in males
| GWAS snp
|
| PMID
|
[PMID 23303382]
|
| Trait
|
Hematology traits
|
| Title
|
Genome-wide association study of serum albumin:globulin ratio in Korean populations.
|
| Risk Allele
|
G
|
| P-val
|
4E-8
|
| Odds Ratio
|
.02 [0.011-0.023] unit increase
|
[PMID 25646338] Genetic loci associated with circulating phospholipid trans fatty acids: a meta-analysis of genome-wide association studies from the CHARGE Consortium
]
