|(G;G)||common; higher LDL-C and total cholesterol|
|(G;T)||common; higher LDL-C and total cholesterol|
|(T;T)||2||lower LDL-C and total cholesterol|
rs174537 is a SNP near the FADS1 gene on chromosome 11. The FADS1 gene is one of 3 fatty acid desaturases in this region; higher polyunsaturated fatty acids (PUFA) levels are generally correlated with lower risk for heart disease.
A study of 1,075 participants in the InCHIANTI study on aging concluded that rs174537(T;T) individuals had lower arachidonic acid (AA), as well as lower levels of all other polyunsaturates measured (excepting linoleic acid, which followed the opposite pattern, and alpha-linoleic acid), compared to (G;G) homozgyotes (p = 6 x 10e-46), and that this one SNP accounted for almost 19% of the variance in AA levels. Individuals carrying at least one rs174537(G) allele had higher low-density lipoprotein (LDL-C) and total cholesterol levels. This effect of rs174537 was confirmed in an independent sample of 1,076 participants in the GOLDN study.[PMID 19148276]
[PMID 19060910] Genome-wide association analysis of metabolic traits in a birth cohort from a founder population.
[PMID 19798445] Genetic determinants of circulating sphingolipid concentrations in European populations.
[PMID 20562440] FADS genetic variants and omega-6 polyunsaturated fatty acid metabolism in a homogeneous island population.
[PMID 20565855] Genetic variation in lipid desaturases and its impact on the development of human disease.
[PMID 21040914] FADS gene polymorphisms in Koreans: association with omega6 polyunsaturated fatty acids in serum phospholipids, lipid peroxides, and coronary artery disease.
[PMID 21115529] Genetics and genomics of human ageing.
[PMID 21383846] Genetic variants of the FADS gene cluster and ELOVL gene family, colostrums LC-PUFA levels, breastfeeding, and child cognition.
[PMID 23285256] Prostatic alpha-linolenic acid (ALA) is positively associated with aggressive prostate cancer: a relationship which may depend on genetic variation in ALA metabolism
[PMID 23160180] Genetic variation at the FADS1-FADS2 gene locus influences delta-5 desaturase activity and LC-PUFA proportions after fish oil supplement.
[PMID 24962583] Relationship between a Common Variants in the Fatty Acid Desaturase (FADS) Cluster and Eicosanoid Generation in Humans
|Title||Large-scale genetic study in East Asians identifies six new loci associated with colorectal cancer risk.|
|Odds Ratio||1.16 [1.12-1.19]|
[PMID 28957329] Uncovering the DNA methylation landscape in key regulatory regions within the FADS cluster.
[PMID 29080057] Sex Differences in Blood HDL-c, the Total Cholesterol/HDL-c Ratio, and Palmitoleic Acid are Not Associated with Variants in Common Candidate Genes.