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rs174537

From SNPedia

Orientationplus
Stabilizedplus
Geno Mag Summary
(G;G) common; higher LDL-C and total cholesterol
(G;T) common; higher LDL-C and total cholesterol
(T;T) 2 lower LDL-C and total cholesterol
ReferenceGRCh38 38.1/141
Chromosome11
Position61785208
GeneMYRF
is asnp
is mentioned by
dbSNPrs174537
ClinGenrs174537
ebirs174537
HLIrs174537
Exacrs174537
Varsomers174537
Maprs174537
PheGenIrs174537
hapmaprs174537
1000 genomesrs174537
hgdprs174537
ensemblrs174537
gopubmedrs174537
geneviewrs174537
scholarrs174537
googlers174537
pharmgkbrs174537
gwascentralrs174537
openSNPrs174537
23andMers174537
23andMe allrs174537
SNP Nexus

SNPshotrs174537
SNPdbers174537
MSV3drs174537
GWAS Ctlgrs174537
GMAF0.3329
Max Magnitude2
? (G;G) (G;T) (T;T) 28
rs174537 is a SNP near the FADS1 gene on chromosome 11. The FADS1 gene is one of 3 fatty acid desaturases in this region; higher polyunsaturated fatty acids (PUFA) levels are generally correlated with lower risk for heart disease.

A study of 1,075 participants in the InCHIANTI study on aging concluded that rs174537(T;T) individuals had lower arachidonic acid (AA), as well as lower levels of all other polyunsaturates measured (excepting linoleic acid, which followed the opposite pattern, and alpha-linoleic acid), compared to (G;G) homozgyotes (p = 6 x 10e-46), and that this one SNP accounted for almost 19% of the variance in AA levels. Individuals carrying at least one rs174537(G) allele had higher low-density lipoprotein (LDL-C) and total cholesterol levels. This effect of rs174537 was confirmed in an independent sample of 1,076 participants in the GOLDN study.[PMID 19148276OA-icon.png]

OMIM612795
DescPOLYUNSATURATED FATTY ACIDS PLASMA LEVEL QUANTITATIVE TRAIT LOCUS
Variant
Relatedalso
[PMID 19060910OA-icon.png] Genome-wide association analysis of metabolic traits in a birth cohort from a founder population.

[PMID 19798445OA-icon.png] Genetic determinants of circulating sphingolipid concentrations in European populations.

[PMID 20562440OA-icon.png] FADS genetic variants and omega-6 polyunsaturated fatty acid metabolism in a homogeneous island population.

[PMID 20565855OA-icon.png] Genetic variation in lipid desaturases and its impact on the development of human disease.

[PMID 21040914] FADS gene polymorphisms in Koreans: association with omega6 polyunsaturated fatty acids in serum phospholipids, lipid peroxides, and coronary artery disease.

[PMID 21115529OA-icon.png] Genetics and genomics of human ageing.

[PMID 21383846OA-icon.png] Genetic variants of the FADS gene cluster and ELOVL gene family, colostrums LC-PUFA levels, breastfeeding, and child cognition.


[PMID 23285256OA-icon.png] Prostatic alpha-linolenic acid (ALA) is positively associated with aggressive prostate cancer: a relationship which may depend on genetic variation in ALA metabolism


[PMID 23160180OA-icon.png] Genetic variation at the FADS1-FADS2 gene locus influences delta-5 desaturase activity and LC-PUFA proportions after fish oil supplement.


[PMID 24962583OA-icon.png] Relationship between a Common Variants in the Fatty Acid Desaturase (FADS) Cluster and Eicosanoid Generation in Humans

GWAS snp
PMID [PMID 24836286OA-icon.png]
Trait Colorectal cancer
Title Large-scale genetic study in East Asians identifies six new loci associated with colorectal cancer risk.
Risk Allele G
P-val 9E-21
Odds Ratio 1.16 [1.12-1.19]