The presence of an rs173686(C) allele has been linked to increased risk of a certain type of stroke, Intracranial Aneurysm, in a population of Dutch adults. [PMID 16917090]
A study of 240 Chinese Han nationality patients with at least one intracranial aneurysm and matched controls did not replicate this result.[PMID 18484070]
Note: the dbSNP sequence entry for this SNP represents the noncoding strand, and is thus the reverse complement compared to the SNP as referred to in [PMID 16917090].
[PMID 30121816] Genetic Risk Factors for Intracranial Aneurysm in the Kazakh Population.
[PMID 31970092] The Association between Genes Polymorphisms of Heparan Sulfate Proteoglycan 2 (HSPG2) and Chondroitin Sulfate Proteoglycan 2 (CSPG2) and Intracranial Aneurysm Susceptibility: A Meta-Analysis.