rs17293443

plus

Geno	Mag	Summary
(C;C)	1.5	slightly higher odds of giving birth to fraternal twins
(C;T)	1.5	slightly higher odds of giving birth to fraternal twins
(T;T)	0	common/normal

Reference

GRCh38.p2 38.2/147

Chromosome

15

Position

67145525

Gene

SMAD3

is a	snp
is	mentioned by
dbSNP	rs17293443
dbSNP (classic)	rs17293443
ClinGen	rs17293443
ebi	rs17293443
HLI	rs17293443
Exac	rs17293443
Gnomad	rs17293443
Varsome	rs17293443
LitVar	rs17293443
Map	rs17293443
PheGenI	rs17293443
Biobank	rs17293443
1000 genomes	rs17293443
hgdp	rs17293443
ensembl	rs17293443
geneview	rs17293443
scholar	rs17293443
google	rs17293443
pharmgkb	rs17293443
gwascentral	rs17293443
openSNP	rs17293443
23andMe	rs17293443
SNPshot	rs17293443
SNPdbe	rs17293443
MSV3d	rs17293443
GWAS Ctlg	rs17293443

Max Magnitude

1.5

?

(C;C) (C;T) (T;T)

28

A meta-analysis found that the less common allele for this SNP, rs17293443(C), is actually associated with a slightly higher likelihood of giving birth to fraternal (dizygotic) twins (odds ratio 1.27, CI:1.19–1.35, p= 1.57 × 10e−8) compared to carriers of the (T) allele. A subsequent replication study of Icelanders yielded lower odds (1.15, CI:1.07–1.23,p=3 × 10e−4).

[PMID 27406421] Two SNPs Associated With Spontaneous Dizygotic Twinning: Effect Sizes and How We Communicate Them.

[PMID 27132594 ] Identification of Common Genetic Variants Influencing Spontaneous Dizygotic Twinning and Female Fertility.

[PMID 30843750] Genetic variants linked to folliculogenesis and successful pregnancy are not associated with twin births in a twins' town.