|?|| (C;C) (C;T) (T;T) ||28|
One study found no significant association between the rs17125944 polymorphism and late-onset Alzheimer's disease (LOAD) in a Chinese Han population, with or without stratification by apolipoprotein E (APOE) ε4 genotype and multivariate logistic regression analysis. When the investigators performed a meta-analysis in 81908 individuals including their study population, they confirmed a previously-reported association between the C allele and LOAD in Caucasian subjects (OR = 1.15, 95 % CI = 1.10–1.20) and in the population as a whole, but not in Chinese subjects.
[PMID 27244899] FERMT2 rs17125944 polymorphism with Alzheimer's disease risk: a replication and meta-analysis.
[PMID 24788522] Genetic variation at the CELF1 (CUGBP, elav-like family member 1 gene) locus is genome-wide associated with Alzheimer's disease and obesity
[PMID 26543236] Risk prediction for sporadic Alzheimer's disease using genetic risk score in the Han Chinese population
FERMT2 Is Associated with Brain Amyloidosis in Cognitively Normal and Mild Cognitive Impairment Subjects