rs1625579
| Orientation | minus |
| Stabilized | minus |
| Geno | Mag | Summary |
|---|---|---|
| (C;C) | 0 |
| Make rs1625579(A;A) |
| Make rs1625579(A;C) |
| Reference | GRCh38 38.1/141 |
| Chromosome | 1 |
| Position | 98037378 |
| Gene | MIR137HG |
| is a | snp |
| is | mentioned by |
| dbSNP | rs1625579 |
| dbSNP (classic) | rs1625579 |
| ClinGen | rs1625579 |
| ebi | rs1625579 |
| HLI | rs1625579 |
| Exac | rs1625579 |
| Gnomad | rs1625579 |
| Varsome | rs1625579 |
| LitVar | rs1625579 |
| Map | rs1625579 |
| PheGenI | rs1625579 |
| Biobank | rs1625579 |
| 1000 genomes | rs1625579 |
| hgdp | rs1625579 |
| ensembl | rs1625579 |
| geneview | rs1625579 |
| scholar | rs1625579 |
| rs1625579 | |
| pharmgkb | rs1625579 |
| gwascentral | rs1625579 |
| openSNP | rs1625579 |
| 23andMe | rs1625579 |
| SNPshot | rs1625579 |
| SNPdbe | rs1625579 |
| MSV3d | rs1625579 |
| GWAS Ctlg | rs1625579 |
| GMAF | 0.1882 |
| Max Magnitude | 0 |
| ? | (A;A) (A;C) (C;C) | 28 |
|---|---|---|
|
| ||
[PMID 21926974
] schizophrenia, p = 1.6 x 10^-11, top hit in a rather large combined sample of (stage 1) 21,856 Europeans and (stage 2, replication) 29,839 independent individuals, see also this post on the Schizophrenia Research Forum
Per the above reference, this SNP is located within an intron of miR-137 / MIR137 (on Wikipedia). Four other additional loci containing predictive targets of this microRNA also passed the threshold for genome-wide significance.. potentially suggesting some involvement of miR-137 mediated activity in the disease.
[PMID 22733126] Genome-wide supported variant MIR137 and severe negative symptoms predict membership of an impaired cognitive subtype of schizophrenia.
[PMID 22982201] Mood congruent psychotic symptoms and specific cognitive deficits in carriers of the novel schizophrenia risk variant at MIR-137
[PMID 22910404] Genetic association study of the P300 endophenotype in schizophrenia
| GWAS snp | |
|---|---|
| PMID | [PMID 23453885]
|
| Trait | Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) |
| Title | Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis. |
| Risk Allele | |
| P-val | 2E-11 |
| Odds Ratio | NR NR |
[PMID 23786914] Analysis of miR-137 expression and rs1625579 in dorsolateral prefrontal cortex
[PMID 22850735] Impact of a microRNA MIR137 susceptibility variant on brain function in people at high genetic risk of schizophrenia or bipolar disorder.
[PMID 22883350] Experimental validation of candidate schizophrenia gene ZNF804A as target for hsa-miR-137.
[PMID 23459466] The genome-wide supported microRNA-137 variant predicts phenotypic heterogeneity within schizophrenia.
[PMID 24820543] Genome-wide schizophrenia variant at MIR137 does not impact white matter microstructure in healthy participants
[PMID 25084801] Association of microRNA137 Gene Polymorphisms with Age at Onset and Positive Symptoms of Schizophrenia in a Han Chinese Population
[PMID 25241074] Lack of association between microRNA-137 SNP rs1625579 and schizophrenia in a replication study of Han Chinese
[PMID 25250332] Association of a miRNA-137 Polymorphism with Schizophrenia in a Southern Chinese Han Population
[PMID 26429811] A GWAS SNP for Schizophrenia Is Linked to the Internal MIR137 Promoter and Supports Differential Allele-Specific Expression
[PMID 27095331] The SNP rs1625579 in miR-137 gene and risk of schizophrenia in Chinese population: A meta-analysis.
[PMID 27481827] Testing the Validity of Taxonic Schizotypy Using Genetic and Environmental Risk Variables.
[PMID 32525059] Genetic underpinnings of schizophrenia-related electroencephalographical intermediate phenotypes: A systematic review and meta-analysis.
[PMID 32910167] The MIR137 VNTR rs58335419 Is Associated With Cognitive Impairment in Schizophrenia and Altered Cortical Morphology.
