|(A;A)||2||slightly lower risk of breast cancer|
|(A;C)||2||slightly lower risk of breast cancer|
|(C;C)||most common genotype|
rs1501299, also known as c.276G>T, represents an intronic variant in the ADIPOQ gene on chromosome 3. It is perhaps the most studied of the common ADIPOQ gene variants; most studies report that the less common rs1501299(A) allele, as oriented in dbSNP, is associated with decreased cancer risk compared with the more common (C) allele.
A study of 733 breast cancer cases for 10 SNPs concluded that the rs1501299(C;C) genotype (in dbSNP orientation) was at increased risk (odds ratio 1.80, CI: 1.14 - 2.85). After categorizing individuals by adiponectin signaling status, this study found that compared with low signalers (the most frequent), intermediate signalers had a 0.64x decrease in breast cancer risk (CI: 0.49–0.83), and high signalers had a 0.15x lower breast cancer risk (CI: 0.02–1.28, p(trend) = 0.001).[PMID 18451143]
Adiponectin signaling status was assigned as follows (as oriented in dbSNP):
rs1501299(C,C) + rs2241766(T,T) = low signaler
rs1501299(A,C) + rs2241766(T,T) = low signaler
rs1501299(C,C) + rs2241766(G,T) = low signaler
rs1501299(A,A) + rs2241766(T,T) = intermediate signaler
rs1501299(A,C) + rs2241766(G,T) = intermediate signaler
rs1501299(C,C) + rs2241766(G,G) = intermediate signaler
rs1501299(A,C) + rs2241766(G,G) = high signaler
rs1501299(A,A) + rs2241766(G,G) = high signaler
rs1501299(A,A) + rs2241766(G,T) = high signaler
Note that adiponectin, a hormone produced by adipose tissue (body fat), is involved in lipid metabolism as well as glucose regulation.
In other words, you are a low adiponectin signaler, and thus have basically average breast cancer risk, if you have one of these combinations of alleles:
You are an intermediate adiponectin signaler (Gs325), and thus possibly at 0.64x reduced risk of breast cancer compared to low signallers, if you have one of these combinations of alleles:
- rs1501299 CC and also rs2241766 GG
- rs1501299 AC and also rs2241766 GT
- rs1501299 AA and also rs2241766 TT
You are a high adiponectin signaler (Gs326), and thus have the lowest (perhaps 0.15x) risk if you have one of these combinations of alleles:
This is one of the SNPs reported by NutraHacker.
[PMID 19696691] Low Serum Adiponectin Levels Are Associated With Systemic Organ Failure in Acute Pancreatitis
[PMID 19631916] Association study of the single nucleotide polymorphisms in adiponectin-associated genes with type 2 diabetes in Han Chinese
[PMID 19761474] Circulating high molecular weight adiponectin isoform is heritable and shares a common genetic background with insulin resistance in nondiabetic White Caucasians from Italy: evidence from a family-based study
[PMID 20414354] Analysis of adiponectin gene polymorphisms in chinese population with systemic lupus erythematosus
[PMID 20576642] Adiponectin gene polymorphisms and their effect on the risk of myocardial infarction and type 2 diabetes: an association study in an Italian population
[PMID 20664545] Relationships among adiponectin gene polymorphisms, proteinuria and increased blood pressure in the context of placental diseases
[PMID 20697428] Genetic variation in adiponectin (ADIPOQ) and the type 1 receptor (ADIPOR1), obesity and prostate cancer in African Americans
[PMID 21397927] Polymorphisms of ADIPOQ and ADIPOR1 and prostate cancer risk
[PMID 21516303] Common genetic variation in adiponectin, leptin, and leptin receptor and association with breast cancer subtypes
[PMID 21630088] Genetic effects of adiponectin single nucleotide polymorphisms on the clustering of metabolic risk factors in young Korean adults
[PMID 21637951] A common variant in the adiponectin gene and polycystic ovary syndrome risk
[PMID 21694446] Associations of single nucleotide polymorphisms in the adiponectin gene with adiponectin levels and cardio-metabolic risk factors in patients with cancer
[PMID 21726267] A Meta-analysis on the Association of Adiponectin Gene Polymorphisms with Coronary Heart Disease in Chinese Han Population
[PMID 21562092] Single nucleotide polymorphisms at the ADIPOQ gene locus interact with age and dietary intake of fat to determine serum adiponectin in subjects at risk of the metabolic syndrome
[PMID 22040602] Recessive protective effect of ADIPOQ rs1501299 on cardiovascular diseases with type 2 diabetes: A meta-analysis
[PMID 22459242] Association of ADIPOQ variants, total and high molecular weight adiponectin levels with coronary artery disease in diabetic and non-diabetic Brazilian subjects
[PMID 22714914] Common polymorphisms (rs2241766 and rs1501299) in the ADIPOQ gene are not associated with hypertension susceptibility among the Chinese
[PMID 22748670] Association of the adiponectin gene rs1501299 G>T variant, serum adiponectin levels, and the risk of coronary artery disease in a Chinese population
[PMID 15616038] Linkage of plasma adiponectin levels to 3q27 explained by association with variation in the APM1 gene.
[PMID 16990411] Association of adiponectin gene variations with risk of incident myocardial infarction and ischemic stroke: a nested case-control study.
[PMID 17712123] Single nucleotide polymorphisms at the adiponectin locus and risk of coronary heart disease in men and women.
[PMID 18398047] Single nucleotide polymorphisms in obesity-related genes and the risk of esophageal cancers.
[PMID 18523726] Adiponectin gene ADIPOQ SNP associations with serum adiponectin in two female populations and effects of SNPs on promoter activity.
[PMID 18603647] Functional genetic polymorphisms and female reproductive disorders: Part I: Polycystic ovary syndrome and ovarian response.
[PMID 18716158] Adiponectin gene variants are associated with insulin sensitivity in response to dietary fat consumption in Caucasian men.
[PMID 18776141] Common variants in the adiponectin gene (ADIPOQ) associated with plasma adiponectin levels, type 2 diabetes, and diabetes-related quantitative traits: the Framingham Offspring Study.
[PMID 18827209] Variants of the adiponectin (ADIPOQ) and adiponectin receptor 1 (ADIPOR1) genes and colorectal cancer risk.
[PMID 19037660] The association of SNPs in ADIPOQ, ADIPOR1, and ADIPOR2 with insulin sensitivity in a cohort of adolescents and their parents.
[PMID 19056609] Association of adiponectin gene polymorphisms with type 2 diabetes in an African American population enriched for nephropathy.
[PMID 19238139] ADIPOQ polymorphisms, monounsaturated fatty acids, and obesity risk: the GOLDN study.
[PMID 19543786] ADIPOQ gene polymorphism rs1501299 interacts with fibre intake to affect adiponectin concentration in children: the GENe-Diet Attica Investigation on childhood obesity.
[PMID 19755407] Association of the +45T>G and +276G>T polymorphisms in the adiponectin gene with insulin resistance in nondiabetic Greek women.
[PMID 19912668] Design and evaluation of a treatment programme for Spanish adolescents with overweight and obesity. The EVASYON Study.
[PMID 20201642] Associations of polymorphisms in adiponectin and leptin genes with men's longevity.
[PMID 20230294] Analysis of adiponectin gene polymorphisms in dilated cardiomyopathy in a Han Chinese population.
[PMID 20421984] FAM-MDR: a flexible family-based multifactor dimensionality reduction technique to detect epistasis using related individuals.
[PMID 20528971] Low plasma adiponectin concentration is associated with myocardial infarction in young individuals.
[PMID 20835900] Genetics of diabetes complications.
[PMID 20848215] Association of adiponectin gene polymorphisms with the risk of ischemic stroke in a Chinese Han population.
[PMID 21054480] Genetic effects of adiponectin on blood lipids and blood pressure.
[PMID 21073447] Lack of association between ADIPOQ rs266729 and ADIPOQ rs1501299 polymorphisms and cardiovascular disease in rheumatoid arthritis patients.
[PMID 21219602] Association of ADIPOQ gene variants with body weight, type 2 diabetes and serum adiponectin concentrations: the Finnish Diabetes Prevention Study.
[PMID 21623778] Adiponectin in chronic heart failure: influence of diabetes and genetic variants.
[PMID 21638131] Associations between single-nucleotide polymorphisms (+45T>G, +276G>T, -11377C>G, -11391G>A) of adiponectin gene and type 2 diabetes mellitus: a systematic review and meta-analysis.
[PMID 21820140] The relationship between adiponectin, an adiponectin gene polymorphism, and high-density lipoprotein particle size: from the Mima study.
[PMID 22386722] Association of ADIPOQ gene polymorphisms and coronary artery disease risk: a meta-analysis based on 12 465 subjects.
[PMID 22391941] Meta-analysis of association studies between five candidate genes and type 2 diabetes in Chinese Han population.
[PMID 22565227] Genetic variants in IGF-I, IGF-II, IGFBP-3, and adiponectin genes and colon cancer risk in African Americans and Whites.
[PMID 22583123] Association of TCF7L2 and ADIPOQ with Body Mass Index, Waist-Hip Ratio, and Systolic Blood Pressure in an Endogamous Ethnic Group of India.
[PMID 23041095] Genetic variability on adiponectin gene affects myocardial infarction risk: The role of endothelial dysfunction
[PMID 23151860] +276 G/T single nucleotide polymorphism of the adiponectin gene is associated with the susceptibility to biliary atresia
[PMID 23200411] ADIPOQ gene polymorphisms and cancer risk: A meta-analysis
[PMID 23370338] Adiponectin gene polymorphisms may not be associated with idiopathic premature ovarian failure
[PMID 23590551] Common variants in adiponectin gene are associated with coronary artery disease and angiographical severity of coronary atherosclerosis in type 2 diabetes
[PMID 23624817] Adiponectin pathway polymorphisms and risk of breast cancer in African Americans and Hispanics in the Women's Health Initiative
[PMID 23653335] AdipoQ polymorphisms are associated with type 2 diabetes mellitus: a meta-analysis study
[PMID 23658423] Adiponectin Gene Variant Interacts with Fish Oil Supplementation to Influence Serum Adiponectin in Older Individuals
[PMID 23740135] The adiponectin gene single-nucleotide polymorphism rs1501299 is associated with hepatocellular carcinoma risk
[PMID 23803590] Polymorphisms of the adiponectin gene in gestational hypertension and pre-eclampsia
[PMID 23260797] Variants of the adiponectin gene and diabetic microvascular complications in patients with type 2 diabetes
[PMID 23819115] Association of Atherosclerotic Peripheral Arterial Disease with Adiponectin Genes SNP+45 and SNP+276: A Case-Control Study
[PMID 23922565] Association of Adiponectin rs1501299 and rs266729 Gene Polymorphisms With Nonalcoholic Fatty Liver Disease
[PMID 24055485] Genetic association of ADIPOQ gene variants with type 2 diabetes, obesity and serum adiponectin levels in south Indian population
[PMID 24559720] Family-based analysis of adiponectin gene polymorphisms in Chinese Han polycystic ovary syndrome
[PMID 23065236] The roles of ADIPOQ genetic variations in cancer risk: evidence from published studies.
[PMID 23225349] Three adiponectin rs1501299G/T, rs822395A/C, and rs822396A/G polymorphisms and risk of cancer development: a meta-analysis.
[PMID 23552441] Association of adiponectin gene polymorphism with birth weight in Korean neonates.
[PMID 25074391] Correlation of serum adiponectin and adiponectin gene polymorphism with metabolic syndrome in Chinese adolescents
[PMID 25135112] Assessment of type 2 diabetes risk conferred by SNPs rs2241766 and rs1501299 in the ADIPOQ gene, a case/control study combined with meta-analyses
[PMID 25223469] Association of ADIPOQ polymorphisms with obesity risk: A meta-analysis
[PMID 26184318] Relation between ADIPOQ Gene Polymorphisms and Type 2 Diabetes
[PMID 25224558] Association of variants in genes related to the immune response and obesity with BPH in CLUE II
[PMID 26221375] Association analysis of genetic variants of adiponectin gene and risk of pancreatic cancer
[PMID 26329379] Adiponectin Gene Polymorphisms are Associated with Increased Risk of Colorectal Cancer
[PMID 26386690] Association Between Single Nucleotide Polymorphism +276G > T (rs1501299) in ADIPOQ and Endometrial Cancer
[PMID 26546898] Plasma Adiponectin Concentrations and Adiponectin Gene Polymorphisms Are Associated with Bronchial Asthma in the Chinese Li Population
[PMID 26865047] Association of adiponectin gene polymorphisms and additional gene-gene interaction with nonalcoholic fatty liver disease in the Chinese Han population.
[PMID 26884098] Single Nucleotide Polymorphism (SNP) in the Adiponectin Gene and Cardiovascular Disease.
[PMID 26887769] [Case-control based study between polymorphisms in the adiponectin gene and polycystic ovary syndrome].
[PMID 27159547] Adipokine Gene Single-Nucleotide Polymorphisms in Portuguese Obese Adolescents: Associations with Plasma Concentrations of Adiponectin, Resistin, IL-6, IL-1β, and TNF-α.
[PMID 28737466] Association of AdipoQ single-nucleotide polymorphisms and smoking interaction with the risk of coronary heart disease in Chinese Han population.
[PMID 29428584] The preliminary association study of ADIPOQ, RBP4, and BCMO1 variants with polycystic ovary syndrome and with biochemical characteristics in a cohort of Polish women.
[PMID 29629043] Lower Levels of Serum Adiponectin and the T Allele of rs1501299 of the ADIPOQ Gene Are Protective against Polycystic Ovarian Syndrome in Jordan.
[PMID 29633340] Contribution of adiponectin polymorphisms to the risk of coronary artery disease in a North-African Tunisian population.
[PMID 30360393] Association of Adiponectin and rs1501299 of the ADIPOQ Gene with Prediabetes in Jordan.
[PMID 30678425] Single Nucleotide Polymorphism in Adiponectin Gene and Risk of Pancreatic Adenocarcinoma
[PMID 30735485] Correlation Between Adiponectin Gene rs1501299 Polymorphism and Nonalcoholic Fatty Liver Disease Susceptibility: A Systematic Review and Meta-Analysis.
[PMID 30883598] ADIPOQ rs2241766 SNP as protective marker against DIBC development in Mexican population.
[PMID 31038568] Adipokine gene variability and plasma levels in patients with chronic periodontitis -a case-control study.
[PMID 31538300] Association of single nucleotide polymorphisms of adiponectin and leptin genes with breast cancer.
[PMID 32345671] The Role of Circulating Adiponectin and SNP276G>T at ADIPOQ Gene in BRCA-mutant Women.