rs1495965
| Orientation | minus |
| Stabilized | minus |
| Geno | Mag | Summary |
|---|---|---|
| (A;A) | 0 | 1.2x higher risk for spondylitis |
| (A;G) | 1.2x higher risk for spondylitis | |
| (G;G) | normal risk | |
| (T;T) | 0 |
| Reference | GRCh38 38.1/141 |
| Chromosome | 1 |
| Position | 67287825 |
| Gene | IL23R |
| is a | snp |
| is | mentioned by |
| dbSNP | rs1495965 |
| dbSNP (classic) | rs1495965 |
| ClinGen | rs1495965 |
| ebi | rs1495965 |
| HLI | rs1495965 |
| Exac | rs1495965 |
| Gnomad | rs1495965 |
| Varsome | rs1495965 |
| LitVar | rs1495965 |
| Map | rs1495965 |
| PheGenI | rs1495965 |
| Biobank | rs1495965 |
| 1000 genomes | rs1495965 |
| hgdp | rs1495965 |
| ensembl | rs1495965 |
| geneview | rs1495965 |
| scholar | rs1495965 |
| rs1495965 | |
| pharmgkb | rs1495965 |
| gwascentral | rs1495965 |
| openSNP | rs1495965 |
| 23andMe | rs1495965 |
| SNPshot | rs1495965 |
| SNPdbe | rs1495965 |
| MSV3d | rs1495965 |
| GWAS Ctlg | rs1495965 |
| GMAF | 0.4522 |
| Max Magnitude | 0 |
| ? | (A;A) (A;G) (G;G) | 28 |
|---|---|---|
|
| ||
rs1495965 is one of several SNPs in the IL23R gene that has been shown in a large (over 1,000 Caucasian patients) study to be associated with ankylosing spondylitis. The odds ratio is 1.2 (p=6.6x10e-6).[PMID 17952073, PMID 18037607]
23andMe reports that the CC genotype at rs1495965 is associated with 1.56x higher odds of Behçet's disease, and the TT genotype with 0.64x lower odds, than the CT genotype. [PMID 20622879]
[PMID 18713787] rs11209032 and rs1495965 no significant association with systemic sclerosis
[PMID 19034457] Lack of association between interleukin 23 receptor gene polymorphisms and rheumatoid arthritis susceptibility
[PMID 19334001] Contribution of IL23R but not ATG16L1 to Crohn's disease susceptibility in Koreans
| GWAS snp | |
|---|---|
| PMID | [PMID 20622879] |
| Trait | Behcet's disease |
| Title | Genome-wide association studies identify IL23R-IL12RB2 and IL10 as Behcet's disease susceptibility loci |
| Risk Allele | G |
| P-val | 2E-11 |
| Odds Ratio | 1.35 [1.24-1.47] |
[PMID 22089529] Associations between interleukin-23R polymorphisms and ankylosing spondylitis susceptibility: a meta-analysis
[PMID 17068223
] A genome-wide association study identifies IL23R as an inflammatory bowel disease gene.
[PMID 17678723] Investigation of the IL23R gene in a Spanish rheumatoid arthritis cohort.
[PMID 17786191] rs1004819 is the main disease-associated IL23R variant in German Crohn's disease patients: combined analysis of IL23R, CARD15, and OCTN1/2 variants.
[PMID 18200510] CARD15 and IL23R influences Crohn's disease susceptibility but not disease phenotype in a Brazilian population.
[PMID 18470928] IL23R haplotypes provide a large population attributable risk for Crohn's disease.
[PMID 19175939] IL23R in the Swedish, Finnish, Hungarian and Italian populations: association with IBD and psoriasis, and linkage to celiac disease.
[PMID 19306001] No association between interleukin 23 receptor gene polymorphisms and systemic lupus erythematosus.
[PMID 20454450] Evidence for STAT4 as a common autoimmune gene: rs7574865 is associated with colonic Crohn's disease and early disease onset.
[PMID 21304977] An investigation of genome-wide studies reported susceptibility loci for ulcerative colitis shows limited replication in north Indians.
[PMID 22378604] Association study of IL10 and IL23R-IL12RB2 in Iranian patients with Behcet's disease.
[PMID 24998354] Determination of IL-23 receptor gene polymorphism in Iranian patients with ankylosing spondylitis
[PMID 29017598] Behçet's disease risk association fine-mapped on the IL23R-IL12RB2 intergenic region in Koreans.
[PMID 29792538] Single-Nucleotide Polymorphisms in IL23R-IL12RB2 (rs1495965) Are Highly Prevalent in Patients with Behcet's Uveitis, and Vary between Populations.
