||Significant (6x) increase in risk for psoriasis, at least in Asians
||Signficant (6x) increase in risk for psoriasis, at least in Asians
rs144475004, also known as c.526G>C, p.Asp176His and D176H, represents a variant in the CARD14 gene on chromosome 17.
In 416 psoriasis patients, the rs144475004(C) allele was associated in Asian individuals with generalized pustular psoriasis (odds ratio 6.4, p=8.4×10e-5), but no CARD14 mutations were found to be associated with other forms of psoriasis vulgaris (PV) or with pityriasis rubra pilaris (PRP).[PMID 26203641]