|Trait||Fasting plasma glucose|
|Title||A variant near MTNR1B is associated with increased fasting plasma glucose levels and type 2 diabetes risk|
|Odds Ratio||0.07 [0.05-0.08] mmol/l increase|
[PMID 19651812] Common genetic variation near melatonin receptor MTNR1B contributes to raised plasma glucose and increased risk of type-2 diabetes amongst Indian Asians and European whites
[PMID 20536959] Two susceptible diabetogenic variants near/in MTNR1B are associated with fasting plasma glucose in a Han Chinese cohort
|Trait||Type 2 diabetes|
|Title||Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis|
|Odds Ratio||1.09 [1.06-1.11]|
[PMID 20858683] Common variants at ten genomic loci influence hemoglobin A1C levels via glycemic and non-glycemic pathways
|Title||A Bivariate Genome-Wide Approach to Metabolic Syndrome: STAMPEED Consortium|
|Odds Ratio||0.2100 [0.15-0.27] unit decrease|
[PMID 21658282] Melatonin Receptor 1 B Polymorphisms associated with the risk of Gestational Diabetes Mellitus
[PMID 22450346] The rs10830963 variant of melatonin receptor MTNR1B is associated with increased risk for gestational diabetes mellitus in a Greek population
[PMID 22768333] Association of Genetic Variants of Melatonin Receptor 1B with Gestational Plasma Glucose Level and Risk of Glucose Intolerance in Pregnant Chinese Women
[PMID 19060907] Variants in MTNR1B influence fasting glucose levels.
[PMID 19324940] G-allele of intronic rs10830963 in MTNR1B confers increased risk of impaired fasting glycemia and type 2 diabetes through an impaired glucose-stimulated insulin release: studies involving 19,605 Europeans.
[PMID 19937311] Common variants at the GCK, GCKR, G6PC2-ABCB11 and MTNR1B loci are associated with fasting glucose in two Asian populations.
[PMID 20628598] Common polymorphisms in MTNR1B, G6PC2 and GCK are associated with increased fasting plasma glucose and impaired beta-cell function in Chinese subjects.
[PMID 20712903] Obesity and diabetes genes are associated with being born small for gestational age: results from the Auckland Birthweight Collaborative study.
[PMID 21445555] Association study of type 2 diabetes genetic susceptibility variants and risk of pancreatic cancer: an analysis of PanScan-I data.
[PMID 21558052] A low frequency variant within the GWAS locus of MTNR1B affects fasting glucose concentrations: Genetic risk is modulated by obesity.
|qualified_impact||Insufficiently evaluated pathogenic|
[PMID 23690305] Genetic variants and the risk of gestational diabetes mellitus: a systematic review
[PMID 23560644] Polymorphisms in genes involved in the free-radical process in patients with sudden sensorineural hearing loss and Meniere's disease.
[PMID 26563312] Relationship between melatonin receptor 1B (rs10830963 and rs1387153) with gestational diabetes mellitus: a case-control study and meta-analysis