| Geno
|
Mag
|
Summary
|
| (C;C)
|
1.5
|
1.59x increased risk of developing bipolar disorder (one study)
|
| (C;T)
|
1.3
|
1.32x increased risk of developing bipolar disorder (one study)
|
| (G;G)
|
0
|
|
| (T;T)
|
1
|
Normal risk of developing bipolar disorder
|
rs1375144, a SNP in the DPP10 gene, has been reported in a large study to be associated with bipolar disorder.
The risk allele (oriented to the dbSNP entry) is (C) ; the odds ratio associated with heterozygotes is 1.32 (CI 1.07-1.63), and for homozygotes, 1.59 (CI 1.29-1.96). [Note: the 2009 citation below did not see a statistically significant difference between cases and controls for this allele in their study.][PMID 17554300
]
| GWAS snp
|
| PMID
|
[PMID 21254220]
|
| Trait
|
|
| Title
|
Propensity score-based nonparametric test revealing genetic variants underlying bipolar disorder.
|
| Risk Allele
|
|
| P-val
|
0.000002
|
| Odds Ratio
|
None None
|
[PMID 19308021] Findings from bipolar disorder genome-wide association studies replicate in a Finnish bipolar family-cohort.
]
