|coronary artery disease risk and periodontitis|
||1.3x increased coronary artery disease risk
||1.5x increased coronary artery disease risk; 2x increased periodontitis risk
rs1333048 increases susceptibility to coronary artery disease 1.30 times for heterozygotes (AC) and 1.54 times for homozygotes (CC) [PMID 17478681]
Study Draws Genetic Link Between Gum, Cardiovascular Disease
|On GW 5.0
|Odds Ratio Het
|Odds Ratio Hom
|Odds Ratio All
||Coronary artery disease (CAD)
[PMID 19214202] rs1333048 2x risk for periodontitis and a confirmation of coronary heart disease
[PMID 20696043] Replication of the association of chromosomal region 9p21.3 with generalized aggressive periodontitis (gAgP) using an independent case-control cohort
[PMID 22430189] Replication of relevant SNPs associated with cardiovascular disease susceptibility obtained from GWAs in a case-control study in a Canarian population
[PMID 18987759] Genetic testing for atherosclerosis risk: inevitability or pipe dream?
[PMID 19578366] Variants in the CDKN2B and RTEL1 regions are associated with high-grade glioma susceptibility.
[PMID 23587006] Validation of reported genetic risk factors for periodontitis in a large-scale replication study
[PMID 28580310] ANRIL Genetic Variants in Iranian Breast Cancer Patients.
[PMID 30600348] Dietary patterns interact with chromosome 9p21 rs1333048 polymorphism on the risk of obesity and cardiovascular risk factors in apparently healthy Tehrani adults.
[PMID 31812071] Genetic variants within ANRIL (antisense non coding RNA in the INK4 locus) are associated with risk of psoriasis.