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rs12770228

From SNPedia

Orientationplus
Stabilizedplus
Geno Mag Summary
(A;A) 2 2x increased risk for meningioma
(A;G) 1.4 1.4x increased risk for meningioma
(G;G) 0
ReferenceGRCh38 38.1/142
Chromosome10
Position21494705
GeneCASC10
is asnp
is mentioned by
dbSNPrs12770228
dbSNP (old)rs12770228
ClinGenrs12770228
ebirs12770228
HLIrs12770228
Exacrs12770228
Gnomadrs12770228
Varsomers12770228
Maprs12770228
PheGenIrs12770228
Biobankrs12770228
1000 genomesrs12770228
hgdprs12770228
ensemblrs12770228
gopubmedrs12770228
geneviewrs12770228
scholarrs12770228
googlers12770228
pharmgkbrs12770228
gwascentralrs12770228
openSNPrs12770228
23andMers12770228
23andMe allrs12770228
SNP Nexus

SNPshotrs12770228
SNPdbers12770228
MSV3drs12770228
GWAS Ctlgrs12770228
GMAF0.1708
Max Magnitude2
? (A;A) (A;G) (G;G) 28
rs12770228 is a SNP in a region on ch 10p12.31 designated as the chromosome 10 open reading frame 114 C10orf114; it is just upstream of the MLLT10 gene.

A study of ~1,600 patients with meningioma, all of European ancestry, concluded that increased risk for the disease was associated with rs12770228(A) alleles. The odds ratio was 1.37 (CI: 1.18-1.59, p = 4 x 10e-4). A nearby SNP, rs11012732, was also linked to meningioma risk.[PMID 21804547OA-icon.png]


[PMID 24755950OA-icon.png] Brain tumor risk according to germ-line variation in the MLLT10 locus


[PMID 28405167OA-icon.png] Genetic variants and increased risk of meningioma: an updated meta-analysis.