|| common in clinvar
|| Hereditary cancer-predisposing syndrome; gastric cancer related?
rs121964876, also known as c.70G>T, p.Glu24Ter, E24* and E24X, represents a very rare mutation in the CDH1 gene on chromosome 16.
This mutation is reported as pathogenic for hereditary diffuse gastric cancer in OMIM (and therefore in ClinVar), inherited dominantly.
23andMe calls rs121964876 by the designation i5004972.
Note also the presence of a different (i5004970, G>A rather than G>T) SNP designation tested by 23andMe at this same position; the G>A change results in a Lysine substitution (instead of the stop codon encoded by the G>T change), with unreported consequences in the literature.