|(C;C)||2||Somewhat increased risk of various types of cancer|
|(T;T)||2||decreased risk for colorectal cancer and lung cancer|
[PMID 25557604] The association of common polymorphisms in miR-196a2 with waist to hip ratio and miR-1908 with serum lipid and glucose
rs11614913 SNP in hsa-mir-196a2 was associated with survival in individuals with NSCLC. Specifically, survival was significantly decreased in individuals who were homozygous CC at SNP rs11614913.
- rs11614913 in hsa-mir-196a2 T>C 1.23; 95% confidence interval [CI], 1.02-1.48
- rs3746444 in hsa-mir-499 A>G OR 1.25; 95% CI, 1.02-1.51
|snp near microRNA|
[PMID 19293314] A Functional Genetic Variant in microRNA-196a2 Is Associated with Increased Susceptibility of Lung Cancer in Chinese.
[PMID 19514064] Functional variant in microRNA-196a2 contributes to the susceptibility of congenital heart disease in a Chinese population
[PMID 19567675] microRNA miR-196a-2 and Breast Cancer: A Genetic and Epigenetic Association Study and Functional Analysis
[PMID 19834808] Association of MicroRNA-196a-2 Gene Polymorphism with Gastric Cancer Risk in a Chinese Population
[PMID 19847796] Evaluation of SNPs in miR-146a, miR196a2 and miR-499 as low-penetrance alleles in German and Italian familial breast cancer cases
[PMID 20188135] Association of a variant in MIR196A2 with susceptibility to hepatocellular carcinoma in male Chinese patients with chronic hepatitis B virus infection
[PMID 20229273] A polymorphism of microRNA196a genome region was associated with decreased risk of glioma in Chinese population
[PMID 20488170] Common genetic polymorphisms in pre-microRNAs were associated with increased risk of dilated cardiomyopathy
[PMID 20501619] Mature miRNA sequence polymorphism in MIR196A2 is associated with risk and prognosis of head and neck cancer
[PMID 20549817] Genetic variants in selected pre-microRNA genes and the risk of squamous cell carcinoma of the head and neck
[PMID 20640596] The association between two polymorphisms in pre-miRNAs and breast cancer risk: a meta-analysis
[PMID 20722507] A functional variation in pre-microRNA-196a is associated with susceptibility of esophageal squamous cell carcinoma risk in Chinese Han
[PMID 20842445] Genetic variation in microRNA genes and prostate cancer risk in North Indian population
[PMID 20848167] Association Study of Common Genetic Variants in Pre-microRNAs in Patients with Ulcerative Colitis
[PMID 21073609] Association Between Common Genetic Variants in Pre-microRNAs and Gastric Cancer Risk in Japanese Population
[PMID 21080878] A variant in microRNA-196a2 is associated with susceptibility to hepatocellular carcinoma in Chinese patients with cirrhosis
[PMID 21241442] A variant in microRNA-196a2 is not associated with susceptibility to and progression of colorectal cancer in Chinese
[PMID 21565628] A Functional Variant in MicroRNA-196a2 Is Associated with Susceptibility of Colorectal Cancer in a Chinese Population
[PMID 21962133] Single Nucleotide Polymorphism in hsa-mir-196a-2 and Breast Cancer Risk: A Case Control Study
[PMID 21565178] Association between SNPs in pre-miRNA and risk of chronic obstructive pulmonary disease
[PMID 22291993] A Genetic Variant in miR-196a2 Increased Digestive System Cancer Risks: A Meta-Analysis of 15 Case-Control Studies
[PMID 22659075] Association of the miR-146aC>G, miR-196a2C>T, and miR-499A>G polymorphisms with moyamoya disease in the Korean population
[PMID 19047128] Single nucleotide polymorphisms of microRNA machinery genes modify the risk of renal cell carcinoma.
[PMID 19138993] Genetic variations in microRNA-related genes are novel susceptibility loci for esophageal cancer risk.
[PMID 19232555] Signatures of purifying and local positive selection in human miRNAs.
[PMID 19290790] MicroRNA polymorphisms: the future of pharmacogenomics, molecular epidemiology and individualized medicine.
[PMID 19423719] Update in lung cancer 2008.
[PMID 19458495] Comprehensive analysis of the impact of SNPs and CNVs on human microRNAs and their regulatory genes.
[PMID 19617315] SNPs in human miRNA genes affect biogenesis and function.
[PMID 19881472] Common genetic variants in pre-microRNAs are associated with risk of coal workers' pneumoconiosis.
[PMID 20428464] MicroRNA polymorphisms: a giant leap towards personalized medicine.
[PMID 20520619] Common genetic variants in pre-microRNAs and risk of gallbladder cancer in North Indian population.
[PMID 21319225] Common genetic polymorphisms in pre-microRNAs and risk of cervical squamous cell carcinoma.
[PMID 21345130] Investigative role of pre-microRNAs in bladder cancer patients: a case-control study in North India.
[PMID 21625865] A genetic variant in microRNA-196a2 is associated with increased cancer risk: a meta-analysis.
[PMID 21663520] Association between single-nucleotide polymorphisms in pre-miRNAs and the risk of asthma in a Chinese population.
[PMID 21692953] A functional polymorphism in pre-microRNA-196a-2 contributes to the susceptibility of hepatocellular carcinoma in a Turkish population: a case-control study.
[PMID 21902575] Genetic variants in miR-146a, miR-149, miR-196a2, miR-499 and their influence on relative expression in lung cancers.
[PMID 22074121] Associations of miRNA polymorphisms and female physiological characteristics with breast cancer risk in Chinese population.
[PMID 22159951] Polymorphisms of miRNAs genes are associated with the risk and prognosis of coronary artery disease.
[PMID 22426473] Lack of association of polymorphism in miRNA-196a2 with Parkinson's disease risk in a Chinese population.
[PMID 22539802] Impact of MiRSNPs on Survival and Progression in Patients with Multiple Myeloma Undergoing Autologous Stem Cell Transplantation.
[PMID 22719192] Evaluation of SNPs in miR-196-a2, miR-27a and miR-146a as risk factors of colorectal cancer
[PMID 23138850] miR-196a Overexpression and miR-196a2 Gene Polymorphism Are Prognostic Predictors of Oral Carcinomas
[PMID 23143626] Hsa-miR-196a2 Functional SNP is Associated With Severe Toxicity After Platinum-Based Chemotherapy of Advanced Nonsmall Cell Lung Cancer Patients in a Chinese Population
[PMID 22818121] The prognostic impact of microRNA sequence polymorphisms on the recurrence of patients with completely resected non-small cell lung cancer
[PMID 23228090] Evaluation of single nucleotide polymorphisms in microRNAs (hsa-miR-196a2 rs11614913 C/T) from Brazilian women with breast cancer
[PMID 23433405] A Single Nucleotide Polymorphism of miR-196a-2 and Vitiligo: An Association Study and Functional Analysis in a Han Chinese Population
[PMID 23470291] Association between Genetic Variants in Pre-MicroRNAs and Survival of Early-Stage NSCLC
[PMID 23516510] Associations of pri-miR-34b/c and pre-miR-196a2 Polymorphisms and Their Multiplicative Interactions with Hepatitis B Virus Mutations with Hepatocellular Carcinoma Risk
[PMID 23219900] Pre-microRNA variants predict HPV16-positive tumors and survival in patients with squamous cell carcinoma of the oropharynx
[PMID 23613771] Polymorphisms of microRNA Sequences or Binding Sites and Lung Cancer: A Meta-Analysis and Systematic Review
[PMID 23728616] Association between genetic variants in pre-miRNA and colorectal cancer risk in a Chinese population
[PMID 23928854] A functional variant of pre-miRNA-196a2 confers risk for Behcet's disease but not for Vogt-Koyanagi-Harada syndrome or AAU in ankylosing spondylitis
[PMID 23791656] Three common functional polymorphisms in microRNA encoding genes in the susceptibility to hepatocellular carcinoma: a systematic review and meta-analysis
[PMID 24254303] Two functional polymorphisms in microRNAs and lung cancer risk: a meta-analysis
[PMID 24291415] Hsa-miR-196a2 polymorphism increases the risk of acute lymphoblastic leukemia in Chinese children
[PMID 24320161] Hsa-miR-196a2 functional SNP is associated with the risk of ESCC in individuals under 60 years old
[PMID 24413317] MicroRNA sequence polymorphisms and the risk of different types of cancer
[PMID 24447667] A common variant in pre-miR-146 is associated with coronary artery disease risk and its mature miRNA expression
[PMID 24568449] Associations of Single Nucleotide Polymorphisms in miR-146a, miR-196a, miR-149 and miR-499 with Colorectal Cancer Susceptibility
[PMID 23001871] Association of the miR-146aC>G, miR-149T>C, miR-196a2T>C, and miR-499A>G polymorphisms with gastric cancer risk and survival in the Korean population.
[PMID 23160898] Quantitative assessment of the association between miR-196a2 rs11614913 polymorphism and gastrointestinal cancer risk.
[PMID 23423813] A functional polymorphism in MIR196A2 is associated with risk and prognosis of gastric cancer.
[PMID 23543085] Association study of genetic variants in miRNAs in patients with inflammatory bowel disease: preliminary results.
[PMID 23593385] Effects of common polymorphism rs11614913 in Hsa-miR-196a2 on lung cancer risk.
[PMID 24039706] The associations of single nucleotide polymorphisms in miR-146a, miR-196a and miR-499 with breast cancer susceptibility
[PMID 24916311] MicroRNAs related polymorphisms and genetic susceptibility to esophageal squamous cell carcinoma
[PMID 24922658] Genetic Polymorphism of miR-196a as a Prognostic Biomarker for Early Breast Cancer
[PMID 24972764] Polymorphism in microRNA-196a2 contributes to the risk of cardiovascular disease in type 2 diabetes patients
[PMID 24978643] Genetic variants of MicroRNA-related genes in susceptibility and prognosis of end-stage renal disease and renal allograft outcome among north Indians
[PMID 25213291] Genetic Polymorphisms in miRNAs and Susceptibility to Colorectal Cancer
[PMID 24681820] Genetic variations in microRNAs and the risk and survival of renal cell cancer
[PMID 25374621] Common genetic variants in pre-microRNAs and risk of breast cancer in the North Indian population
[PMID 25445498] A common polymorphism in pre-miR-146a underlies Hirschsprung disease risk in Han Chinese
[PMID 25795117] Comprehensive assessment of the association between miRNA polymorphisms and gastric cancer risk
[PMID 25896941] miR-196a-2 rs11614913 polymorphism is associated with vitiligo by affecting heterodimeric molecular complexes of Tyr and Tyrp1
[PMID 25176041] High-resolution melting analysis reveals genetic polymorphisms in microRNAs confer hepatocellular carcinoma risk in Chinese patients
[PMID 26112096] Assessment of association between genetic variants in microRNA genes hsa-miR-499, hsa-miR-196a2 and hsa-miR-27a and prostate cancer risk in Serbian population
[PMID 25557604] The association of common polymorphisms in miR-196a2 with waist to hip ratio and miR-1908 with serum lipid and glucose
[PMID 26305248] Variants of MicroRNA Genes: Gender-Specific Associations with Multiple Sclerosis Risk and Severity
[PMID 26406571] The association between two common polymorphisms (miR-146a rs2910164 and miR-196a2 rs11614913) and susceptibility to gastric cancer: A meta-analysis
[PMID 26458899] Common genetic polymorphisms in pre-microRNAs and risk of bladder cancer
[PMID 26518769] Genetic variants in miR-196a2 and miR-499 are associated with susceptibility to esophageal squamous cell carcinoma in Chinese Han population
[PMID 26537765] A Genetic Variant in Pre-miR-146a (rs2910164 C>G) Is Associated with the Decreased Risk of Acute Coronary Syndrome in a Chinese Population
[PMID 26554236] A Functional Single-Nucleotide Polymorphism in Pre-microRNA-196a2 is Associated with Atrial Fibrillation in Han Chinese
[PMID 26608782] Association Between Single-Nucleotide Polymorphism (SNP) in miR-146a, miR-196a2, and miR-499 and Risk of Ischemic Stroke: A Meta-Analysis.
[PMID 26710106] Somatic Mutation of the SNP rs11614913 and Its Association with Increased MIR 196A2 Expression in Breast Cancer.
[PMID 26870188] Association between the rs11614913 variant of miRNA-196a-2 and the risk of epithelial ovarian cancer.
[PMID 26886638] The Associations of Single Nucleotide Polymorphisms in miR196a2, miR-499, and miR-608 With Breast Cancer Susceptibility: A STROBE-Compliant Observational Study.
[PMID 26926727] [Interaction research on smoking and microRNA genes SNP related to lung cancer in Fujian Han population].
[PMID 27173281] Association between the pre-miR-196a2 rs11614913 polymorphism and gastric cancer susceptibility in a Chinese population.
[PMID 27293850] Effects of common polymorphisms in miR-146a and miR-196a2 on lung cancer susceptibility: a meta-analysis.
[PMID 27421647] Association of single nucleotide polymorphisms in Pre-miR-27a, Pre-miR-196a2, Pre-miR-423, miR-608 and Pre-miR-618 with breast cancer susceptibility in a South American population.
[PMID 27509977] Combined Genotype Analyses of Precursor miRNA196a2 and 499a Variants with Hepatic and Renal Cancer Susceptibility a Preliminary Study.
[PMID 27701053] MicroRNA-related polymorphisms and non-Hodgkin lymphoma susceptibility in the Multicenter AIDS Cohort Study.
[PMID 27796868] Effect of rs11614913 Polymorphism on Mature miR196a2 Expression and its Target Gene HOXC8 Expression in Human Glioma.
[PMID 27813602] Association of miR-196a2, miR-27a, and miR-499 polymorphisms with isolated congenital heart disease in a Chinese population.
[PMID 28301487] Association of miR-196a-2 and miR-499 variants with ulcerative colitis and their correlation with expression of respective miRNAs.
[PMID 28922434] Association of microRNA Polymorphisms with the Risk of Gastric Cancer in a Romanian Population.
[PMID 28950676] Association between Microrna 146a and Microrna 196a2 Genes Polymorphism and Breast Cancer Risk in North Indian Women
[PMID 28977965] Genetic polymorphisms of non-coding RNAs associated with increased head and neck cancer susceptibility: a systematic review and meta-analysis.
[PMID 29715515] Contribution of microRNA-149, microRNA-146a, and microRNA-196a2 SNPs in colorectal cancer risk and clinicopathological features in Tunisia.
[PMID 30872409] Impacts of Single Nucleotide Polymorphisms in three MicroRNAs (miR-146a, miR-196a2 and miR-499) on Susceptibility to Cervical Cancer among Indian Women.