||Among COVID-19 patients, more susceptible to respiratory failure
||Among COVID-19 patients, higher respiratory failure susceptibility
Located in an intronic region of chromosome 3, the minor rs11385942(A) allele yielded the strongest association signal across the genome for respiratory failure among COVID-19 patients (OR 1.77, CI:1.5-2.1,p=1.15×10e−10), and also for needing mechanical ventilation. The 19 patients who were homozygous for the minor allele, i.e. had genotype rs11385942(A;A), were also younger than the 1,591 patients who were heterozygous or homozygous for the nonrisk allele (median age, 59 years vs. 66 years; p=0.005).10.1056/NEJMoa2020283
Note that rs11385942 is not present on the DNA chips used by the major direct-to-consumer genotyping companies such as 23andMe, Ancestry and MyHeritage. In Caucasians, a SNP present on most MyHeritage and Ancestry chips, rs10490770, is a very good proxy for rs11385942 (and it is also present on older versions of the 23andMe chip). The minor allele of rs10490770(C) corresponds most of the time (r2 >0.99 in Caucasians) to the minor rs11385942(A) allele based on data available in ensembl. There is no equivalent linkage in those of African descent; and the correlation is lower in Hispanic populations (r2 ~0.8-0.9).