rs1128535
From SNPedia
Orientation | minus |
Stabilized | minus |
Geno | Mag | Summary |
---|---|---|
(A;A) | 0.5 | normal |
(A;G) | 1.8 | 0.77x risk for Crohn's disease |
(G;G) | 2 | reduced risk (0.77x) for Crohn's disease |
Reference | GRCh38 38.1/141 |
Chromosome | 3 |
Position | 49828959 |
Gene | TRAIP |
is a | snp |
is | mentioned by |
dbSNP | rs1128535 |
dbSNP (classic) | rs1128535 |
ClinGen | rs1128535 |
ebi | rs1128535 |
HLI | rs1128535 |
Exac | rs1128535 |
Gnomad | rs1128535 |
Varsome | rs1128535 |
LitVar | rs1128535 |
Map | rs1128535 |
PheGenI | rs1128535 |
Biobank | rs1128535 |
1000 genomes | rs1128535 |
hgdp | rs1128535 |
ensembl | rs1128535 |
geneview | rs1128535 |
scholar | rs1128535 |
rs1128535 | |
pharmgkb | rs1128535 |
gwascentral | rs1128535 |
openSNP | rs1128535 |
23andMe | rs1128535 |
23andMe all | rs1128535 |
SNPshot | rs1128535 |
SNPdbe | rs1128535 |
MSV3d | rs1128535 |
GWAS Ctlg | rs1128535 |
GMAF | 0.393 |
Max Magnitude | 2 |
? | (A;A) (A;G) (G;G) | 28 |
---|---|---|
|
The less common allele of rs1128535, a SNP in the TRAIP gene, may have a protective effect against the development of Crohn's disease, based on a study of 469 Caucasian patients. The reported odds ratio is 0.77 (CI: 0.67-0.89, p=0.002).[PMID 18200509]
Note that rs1128535 is highly correlated (r2 > 0.8) to nonsynonymous SNPs in the nearby MST1R gene, rs2230590 and rs1062633, also known as Arg523Gln and Gly1335Arg, respectively. [PMID 18200509]
[PMID 19657358] Effect of BSN-MST1 locus on inflammatory bowel disease and multiple sclerosis susceptibility