rs1128535
From SNPedia
| Orientation | minus |
| Stabilized | minus |
| Geno | Mag | Summary |
|---|---|---|
| (A;A) | 0.5 | normal |
| (A;G) | 1.8 | 0.77x risk for Crohn's disease |
| (G;G) | 2 | reduced risk (0.77x) for Crohn's disease |
| Reference | GRCh38 38.1/141 |
| Chromosome | 3 |
| Position | 49828959 |
| Gene | TRAIP |
| is a | snp |
| is | mentioned by |
| dbSNP | rs1128535 |
| dbSNP (classic) | rs1128535 |
| ClinGen | rs1128535 |
| ebi | rs1128535 |
| HLI | rs1128535 |
| Exac | rs1128535 |
| Gnomad | rs1128535 |
| Varsome | rs1128535 |
| LitVar | rs1128535 |
| Map | rs1128535 |
| PheGenI | rs1128535 |
| Biobank | rs1128535 |
| 1000 genomes | rs1128535 |
| hgdp | rs1128535 |
| ensembl | rs1128535 |
| geneview | rs1128535 |
| scholar | rs1128535 |
| rs1128535 | |
| pharmgkb | rs1128535 |
| gwascentral | rs1128535 |
| openSNP | rs1128535 |
| 23andMe | rs1128535 |
| 23andMe all | rs1128535 |
| SNPshot | rs1128535 |
| SNPdbe | rs1128535 |
| MSV3d | rs1128535 |
| GWAS Ctlg | rs1128535 |
| GMAF | 0.393 |
| Max Magnitude | 2 |
| ? | (A;A) (A;G) (G;G) | 28 |
|---|---|---|
|
| ||
The less common allele of rs1128535, a SNP in the TRAIP gene, may have a protective effect against the development of Crohn's disease, based on a study of 469 Caucasian patients. The reported odds ratio is 0.77 (CI: 0.67-0.89, p=0.002).[PMID 18200509]
Note that rs1128535 is highly correlated (r2 > 0.8) to nonsynonymous SNPs in the nearby MST1R gene, rs2230590 and rs1062633, also known as Arg523Gln and Gly1335Arg, respectively. [PMID 18200509]
[PMID 19657358] Effect of BSN-MST1 locus on inflammatory bowel disease and multiple sclerosis susceptibility
