[PMID 22763110
] Identification of new susceptibility loci for osteoarthritis (arcOGEN): a genome-wide association study. Published 2012. Found that two SNPs had significance "in perfect linkage disequilibrium (LD) with each other: rs11177 (allele A; figure A), a missense polymorphism within exon three of GNL3, coding for nucleostemin, and rs6976 (allele T; table 2), situated in the 3′ untranslated region (UTR) of the GLT8D1 gene." The OD for rs11177 was 1.09 (p=5·13×10−09) and the OD for rs6976 was 1.09 (p=6·56×10−09).
[PMID 19416921] Genome-wide association and meta-analysis of bipolar disorder in individuals of European ancestry. Published 2009. Found that "The most strongly associated nonsynonymous SNP rs1042779 (OR = 1.19, P = 1.8 × 10−7) is in the ITIH1 gene on chromosome 3, with other strongly associated nonsynonymous SNPs in GNL3, NEK4, and ITIH3." In particular, "Four additional nonsynonymous SNPs in this region had P < 10−5: rs2289247 (Val367Met) and rs11177 Arg27Gln in GNL3 (guanine nucleotide binding like-3), rs1029871 (Pro225Ala) in NEK4, and rs3617 (Gln315Lys) in ITIH3."
[PMID 29942097] Common variants in the GNL3 contribute to the increasing risk of knee osteoarthritis in Han Chinese population.
] Identification of new susceptibility loci for osteoarthritis (arcOGEN): a genome-wide association study. Published 2012. Found that two SNPs had significance "in perfect linkage disequilibrium (LD) with each other: rs11177 (allele A; figure A), a missense polymorphism within exon three of GNL3, coding for nucleostemin, and rs6976 (allele T; table 2), situated in the 3′ untranslated region (UTR) of the GLT8D1 gene." The OD for rs11177 was 1.09 (p=5·13×10−09) and the OD for rs6976 was 1.09 (p=6·56×10−09).
