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rs110419

From SNPedia

Orientationplus
Stabilizedplus
Geno Mag Summary
(A;A) 2 1.7x increased risk for neuroblastoma
(A;G) 1.3 1.3x increased risk for neuroblastoma
(G;G) 0
ReferenceGRCh38 38.1/141
Chromosome11
Position8231306
GeneLMO1, LOC105376536
is asnp
is mentioned by
dbSNPrs110419
dbSNP (old)rs110419
ClinGenrs110419
ebirs110419
HLIrs110419
Exacrs110419
Gnomadrs110419
Varsomers110419
Maprs110419
PheGenIrs110419
Biobankrs110419
1000 genomesrs110419
hgdprs110419
ensemblrs110419
gopubmedrs110419
geneviewrs110419
scholarrs110419
googlers110419
pharmgkbrs110419
gwascentralrs110419
openSNPrs110419
23andMers110419
23andMe allrs110419
SNP Nexus

SNPshotrs110419
SNPdbers110419
MSV3drs110419
GWAS Ctlgrs110419
GMAF0.4054
Max Magnitude2
rs110419 is a SNP in the LMO1 LIM domain only 1 (rhombotin 1) gene.


A GWAS study of 2,000+ patients (and 6,000+ controls) concluded that the rs110419(A) allele is associated with increased risk for neuroblastoma, with an allelic odds ratio of 1.34 (CI: 1.25 - 1.44, combined p = 5.2 x 10e-16).[PMID 21124317OA-icon.png]

? (A;A) (A;G) (G;G) 28
[PMID 18463370OA-icon.png] Chromosome 6p22 locus associated with clinically aggressive neuroblastoma.
GWAS snp
PMID [PMID 22941191OA-icon.png]
Trait Neuroblastoma
Title Common variation at 6q16 within HACE1 and LIN28B influences susceptibility to neuroblastoma.
Risk Allele A
P-val 1E-13
Odds Ratio 1.32 [NR]