rs10989591, aka Val362Met or V362M, is a SNP in the N-methyl-D-aspartate 3A GRIN3A gene, which codes for the N-methyl-D-aspartate 3A subunit of the glutamate N-methyl-D-aspartate receptor. The (C) allele encodes the Val and the (T) allele encodes the Met.
gs278 reflects a gene-gene interaction between this SNP and a DRD2 SNP, rs6277, in which older adults with a particular combination of genotypes at these two (independent) loci are reported to exhibit better episodic memory.
[PMID 17214563] Based on electromagnetic activity during selective attention (auditory oddball task with target processing) measured in 281 healthy subjects, rs10989591(T;T) individuals appeared to show better prefrontal information processing (based on higher frontal P300 amplitudes), presumably reflecting higher NMDA receptor efficacy.
