|(A;T)||1.24x increased stroke risk for males|
|(T;T)||1.24x increased stroke risk for males|
rs10507391, also known as SG13S114, is an ALOX5AP gene SNP that has been defined as part of a haplotype potentially associated with risk for myocardial infarction or ischemic stroke. Details of this haplotype and several related studies are on the ALOX5AP page.
One study that specifically found association for rs10507391 involved 639 German ischemic stroke patients. The association was statistically significant (only) in males, with an odds ratio of 1.24 (CI: 1.04-1.55, p=0.017).[PMID 15731479]
[PMID 20067482] The role of LTA4H and ALOX5AP genes in the risk for asthma in Latinos
[PMID 21153769] A tagging SNP in ALOX5AP and risk of stroke: a haplotype-based analysis among eastern Chinese Han population
[PMID 22051033] ALOX5AP genetic variants and risk of atherothrombotic stroke in the Taiwanese population
[PMID 17903304] Framingham Heart Study 100K project: genome-wide associations for cardiovascular disease outcomes.
[PMID 19130089] Genetic effects in the leukotriene biosynthesis pathway and association with atherosclerosis.
[PMID 19665766] Genetics and pharmacogenetics of the leukotriene pathway.
[PMID 20592751] Human lipoxygenase pathway gene variation and association with markers of subclinical atherosclerosis in the diabetes heart study.
[PMID 20810156] ALOX5AP and LTA4H polymorphisms modify augmentation of bronchodilator responsiveness by leukotriene modifiers in Latinos.
[PMID 23765972] Interaction between ALOX5AP-SG13S114A/T and COX-2-765G/C increases susceptibility to cerebral infarction in a Chinese population
[PMID 24368493] Interaction between ALOX5AP and CYP3A5 gene variants significantly increases the risk for cerebral infarctions in Chinese
[PMID 26885075] A tagging ALOX5AP polymorphism and risk of ischemic stroke in a northeastern Chinese Han population.
[PMID 26944113] Arachidonate 5-lipoxygenase (ALOX5) gene polymorphism is associated with Alzheimer's disease and body mass index.
[PMID 30678701] Genetic variation in the leukotriene pathway is associated with myocardial infarction in the Chinese population.