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rs10490770

From SNPedia

Orientationminus
Stabilizedminus
Geno Mag Summary
(A;A) 0 common/normal
(A;G) 1.7 For Caucasians (only), likely higher respiratory failure odds among COVID-19 patients
(G;G) 3 For Caucasians (only), likely higher respiratory failure odds among COVID-19 patients
is asnp
is mentioned by
dbSNPrs10490770
dbSNP (classic)rs10490770
ClinGenrs10490770
ebirs10490770
HLIrs10490770
Exacrs10490770
Gnomadrs10490770
Varsomers10490770
LitVarrs10490770
Maprs10490770
PheGenIrs10490770
Biobankrs10490770
1000 genomesrs10490770
hgdprs10490770
ensemblrs10490770
geneviewrs10490770
scholarrs10490770
googlers10490770
pharmgkbrs10490770
gwascentralrs10490770
openSNPrs10490770
23andMers10490770
23andMe allrs10490770
SNPshotrs10490770
SNPdbers10490770
MSV3drs10490770
GWAS Ctlgrs10490770
Max Magnitude3

This SNP is primarily of interest as a proxy (i.e. substitute) for rs11385942, a SNP reported in an 2020 study to be associated with higher susceptibility to respiratory failure among COVID-19 patients. The minor allele of both SNPs is associated with somewhat higher risk; see rs11385942 for details.

Note that rs10490770 is defined in dbSNP on the reverse (minus) strand. Therefore, as reported in the raw data from direct-to-consumer genotyping companies such as Ancestry or MyHeritage, the major/common ("good") allele for rs10490770 is 'T', and the minor/risk allele is 'C'. In SNPedia, those alleles are reported in accordance with the original orientation in dbSNP, and are therefore 'A' and 'G', respectively.