Do genetic predictors of pain sensitivity associate with persistent widespread pain? C allele associated with higher pain tolerance.[PMID 19775452
]
GCH1 haplotype determines vascular and plasma biopterin availability in coronary artery disease effects on vascular superoxide production and endothelial function. Part of a haplotype, rs10483639(C)-rs3783641(A)-rs8007267(T), associated with lower levels of tetrahydrobiopterin.[PMID 18598896]
[PMID 17343757] Lack of influence of GTP cyclohydrolase gene (GCH1) variations on pain sensitivity in humans.
[PMID 17363416] Reliable screening for a pain-protective haplotype in the GTP cyclohydrolase 1 gene (GCH1) through the use of 3 or fewer single nucleotide polymorphisms.
[PMID 19751821] Oxidative risk for atherothrombotic cardiovascular disease.
[PMID 20633294] Different SNP combinations in the GCH1 gene and use of labor analgesia.
[PMID 23059057] A GCH1 haplotype and risk of neural tube defects in the National Birth Defects Prevention Study
[PMID 25218601] Epistasis Between Polymorphisms in COMT, ESR1, and GCH1 Influences COMT Enzyme Activity and Pain
]
