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rs1046089

From SNPedia

Orientationplus
Stabilizedplus
Geno Mag Summary
(A;A) normal
(A;G) normal
(G;G) 0.48x risk of malaria
ReferenceGRCh38 38.1/141
Chromosome6
Position31635190
GenePRRC2A
is asnp
is mentioned by
dbSNPrs1046089
ClinGenrs1046089
ebirs1046089
HLIrs1046089
Exacrs1046089
Varsomers1046089
Maprs1046089
PheGenIrs1046089
hapmaprs1046089
1000 genomesrs1046089
hgdprs1046089
ensemblrs1046089
gopubmedrs1046089
geneviewrs1046089
scholarrs1046089
googlers1046089
pharmgkbrs1046089
gwascentralrs1046089
openSNPrs1046089
23andMers1046089
23andMe allrs1046089
SNP Nexus

SNPshotrs1046089
SNPdbers1046089
MSV3drs1046089
GWAS Ctlgrs1046089
GMAF0.3944
Max Magnitude
? (A;A) (A;G) (G;G) 28
rs1046089 is a SNP in the HLA-B associated transcript 2 BAT2 gene.

A study of 2,162 case-controls found an association between rs1046089 and severe malaria.[PMID 19039607OA-icon.png]

GWAS snp
PMID [PMID 22267201OA-icon.png]
Trait
Title Meta-analyses identify 13 loci associated with age at menopause and highlight DNA repair and immune pathways.
Risk Allele A
P-val 2E-16
Odds Ratio 0.2130 None


[PMID 18204098] Association of systemic lupus erythematosus with C8orf13-BLK and ITGAM-ITGAX.


[PMID 19143815OA-icon.png] MHC fine mapping of human type 1 diabetes using the T1DGC data.


GET Evidence
PRRC2A-R1740H
aa_change Arg1740His
aa_change_short R1740H
impact not reviewed
qualified_impact Insufficiently evaluated not reviewed
overall_frequency
summary



GWAS snp
PMID [PMID 23307926OA-icon.png]
Trait Menopause (age at onset)
Title A genome-wide association study of early menopause and the combined impact of identified variants.
Risk Allele A
P-val 4E-11
Odds Ratio .19 [0.13-0.25] years increase
GWAS snp
PMID [PMID 23571483]
Trait Schizophrenia
Title A comprehensive family-based replication study of schizophrenia genes.
Risk Allele G
P-val 4E-6
Odds Ratio 1.30 [NR]
GWAS snp
PMID [PMID 23894747OA-icon.png]
Trait Schizophrenia
Title A comprehensive family-based replication study of schizophrenia genes.
Risk Allele G
P-val 4E-6
Odds Ratio 1.30 [NR]