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rs1042779

From SNPedia

Orientationplus
Stabilizedplus
Make rs1042779(A;A)
Make rs1042779(A;G)
Make rs1042779(G;G)
ReferenceGRCh38 38.1/141
Chromosome3
Position52786995
GeneITIH1
is asnp
is mentioned by
dbSNPrs1042779
dbSNP (old)rs1042779
ClinGenrs1042779
ebirs1042779
HLIrs1042779
Exacrs1042779
Gnomadrs1042779
Varsomers1042779
Maprs1042779
PheGenIrs1042779
Biobankrs1042779
1000 genomesrs1042779
hgdprs1042779
ensemblrs1042779
gopubmedrs1042779
geneviewrs1042779
scholarrs1042779
googlers1042779
pharmgkbrs1042779
gwascentralrs1042779
openSNPrs1042779
23andMers1042779
23andMe allrs1042779
SNP Nexus

SNPshotrs1042779
SNPdbers1042779
MSV3drs1042779
GWAS Ctlgrs1042779
GMAF0.4596
Max Magnitude
? (A;A) (A;G) (G;G) 28
[PMID 19416921OA-icon.png] Genome-wide association and meta-analysis of bipolar disorder in individuals of European ancestry. Published 2009. Found that "The most strongly associated nonsynonymous SNP rs1042779 (OR = 1.19, P = 1.8 × 10−7) is in the ITIH1 gene on chromosome 3, with other strongly associated nonsynonymous SNPs in GNL3, NEK4, and ITIH3." In particular, "Four additional nonsynonymous SNPs in this region had P < 10−5: rs2289247 (Val367Met) and rs11177 Arg27Gln in GNL3 (guanine nucleotide binding like-3), rs1029871 (Pro225Ala) in NEK4, and rs3617 (Gln315Lys) in ITIH3."


[PMID 20081856OA-icon.png] Meta-analysis of genome-wide association data identifies a risk locus for major mood disorders on 3p21.1.. Published 2010. In reference to the 2009 research article cited [PMID 19416921OA-icon.png], "the most significant SNP in that study was nominally significant in the present study (rs1042779; p=0.001).


GET Evidence
ITIH1-Q595R
aa_change Gln595Arg
aa_change_short Q595R
impact not reviewed
qualified_impact Insufficiently evaluated not reviewed
overall_frequency 0.42071
summary



[PMID 24389398] ITIH Family Genes Confer Risk to Schizophrenia and Major Depressive Disorder in the Han Chinese Population