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rs10239794

From SNPedia

Orientationplus
Stabilizedplus
Geno Mag Summary
(C;C) 1 One study reports 1.3x higher risk for ALS
(C;T) 1 One study reports 1.3x higher risk for ALS
(T;T) 0 common/normal
ReferenceGRCh38 38.1/141
Chromosome7
Position154508809
GeneDPP6
is asnp
is mentioned by
dbSNPrs10239794
dbSNP (old)rs10239794
ClinGenrs10239794
ebirs10239794
HLIrs10239794
Exacrs10239794
Varsomers10239794
Maprs10239794
PheGenIrs10239794
Biobankrs10239794
1000 genomesrs10239794
hgdprs10239794
ensemblrs10239794
gopubmedrs10239794
geneviewrs10239794
scholarrs10239794
googlers10239794
pharmgkbrs10239794
gwascentralrs10239794
openSNPrs10239794
23andMers10239794
23andMe allrs10239794
SNP Nexus

SNPshotrs10239794
SNPdbers10239794
MSV3drs10239794
GWAS Ctlgrs10239794
GMAF0.4642
Max Magnitude1
? (C;C) (C;T) (T;T) 28
rs10239794, a SNP in the region of the DPP6 gene on chromosome 7, has been associated with the sporadic form of ALS (Lou Gehrig's disease) in a 2008 study of 1000+ European patients. The odds ratio for the risk allele rs10239794(C) is 1.30 (CI: 1.18 - 1.43). [PMID 18084291]


A "CC" haplotype for this SNP and that of it's neighbor rs10260404 is also highly (statistically; p=10e-9) associated with ALS. [PMID 18084291]

However, a subsequent publication was unable to replicate the association with rs10260404, and to our knowledge, in the years since 2008 there has not been a report replicating the association of rs10239794 with ALS.