||1.7x increased risk for NSAID hypersensitivity
||>2x increased risk for NSAID hypersensitivity
rs10156191, also known as Thr16Met or T16M, represents a variant in the AOC gene on chromosome 7; this gene is also known as the DAO or diamine oxidase. The rs10156191(C) allele encodes the more common Thr amino acid at this position, and the (T) allele encodes the Met. The DAO Met allele is considered to encode a protein with lower metabolic capacity than the Thr allele.[PMID 21488903]
[PMID 23152756] A study of 400 patients showing hypersensitivity to non-steroidal anti-inflammatory drugs (NSAIDs) found an association with the 16M allele (OR 1.7, CI: 1.3 - 2.1, Pc = 0.0003) with a gene-dose effect (P = 0.0001).
[PMID 19450133] Histamine pharmacogenomics
[PMID 21488903] Association of single nucleotide polymorphisms in the diamine oxidase gene with diamine oxidase serum activities. Found reduced DAO activity for the minor allele and lower DAO mRNA expression for the homozygous minor allele.
[PMID 23152756] The Diamine Oxidase Gene Is Associated with Hypersensitivity Response to Non-Steroidal Anti-Inflammatory Drugs
[PMID 27746735] FCERI and Histamine Metabolism Gene Variability in Selective Responders to NSAIDS.