|(C;T)||2||1.4x increased risk for prostate cancer|
|(T;T)||2.1||1.4x increased risk for prostate cancer|
|?||(C;C) (C;T) (T;T)||28|
rs10090154 is a SNP in chromosome 8q24 "region 1", associated with increased risk for prostate cancer. The odds ratio for the (T) risk allele were 1.42 (CI: 1.07-1.87, p=0.014), and they were not significantly different between Caucasians and African-Americans in this study of ~500 patients.[PMID 18231127]
In follow-up studies looking at disease severity (and not just overall risk), this SNP is reported to account for the risk (from region 1) of advanced prostate cancer.[PMID 18231127]
Note that a meta-analysis across 10+ studies, including over 15,000 prostate cancer cases, reported the risk for a different SNP (rs1447295) representing the same region, "region 1", of this chromosome.[PMID 1823127]
[PMID 19857256] Association between an 8q24 locus and the risk of colorectal cancer in Japanese
[PMID 19866473] Association of 17 prostate cancer susceptibility loci with prostate cancer risk in Chinese men
[PMID 21051319] Risk of Urinary Bladder Cancer is Associated with 8q24 Variant rs9642880[T]: Results from the Los Angeles-Shanghai Case-Control Study
[PMID 22549899] Genetic polymorphism and prostate cancer aggressiveness: A case-only study of 1,536 GWAS and candidate SNPs in African-Americans and European-Americans
[PMID 17618282] A common genetic risk factor for colorectal and prostate cancer.
[PMID 18349290] Association of genetic variants at 8q24 with breast cancer risk.
[PMID 18360876] Chromosome 8q24 markers: risk of early-onset and familial prostate cancer.
[PMID 18483343] Multiple independent genetic variants in the 8q24 region are associated with prostate cancer risk.
[PMID 18577746] Multiple loci with different cancer specificities within the 8q24 gene desert.
[PMID 18704501] Comprehensive resequence analysis of a 136 kb region of human chromosome 8q24 associated with prostate and colon cancers.
[PMID 19155440] Meta association of colorectal cancer confirms risk alleles at 8q24 and 18q21.
[PMID 19520795] Novel single nucleotide polymorphism associations with colorectal cancer on chromosome 8q24 in African and European Americans.
[PMID 19680443] Functional enhancers at the gene-poor 8q24 cancer-linked locus.
[PMID 20039378] Estimation of genotype relative risks from pedigree data by retrospective likelihoods.
[PMID 20584312] 8q24 sequence variants in relation to prostate cancer risk among men of African descent: a case-control study.
[PMID 20690139] Meta-analysis of genome-wide and replication association studies on prostate cancer.
[PMID 22099997] Risk loci on chromosome 8q24 are associated with prostate cancer in northern Chinese men.
|Title||Evaluating genetic risk for prostate cancer among Japanese and Latinos.|
|Odds Ratio||1.68 [1.35-2.09]|
[PMID 23935004] Pleiotropic effects of genetic risk variants for other cancers on colorectal cancer risk: PAGE, GECCO and CCFR consortia
[PMID 23628314] A replication study examining association of rs6983267, rs10090154, and rs1447295 common single nucleotide polymorphisms in 8q24 region with prostate cancer in Siberians.