rs10033464
| Orientation | plus |
| Stabilized | plus |
| Geno | Mag | Summary |
|---|---|---|
| (G;G) | 1.9 | 0.92x decreased risk of Atrial Fibrillation and cardioembolic stroke. |
| (G;T) | 3 | 1.28x increased risk of Atrial Fibrillation and cardioembolic stroke. |
| (T;T) | 3 | 1.4x increased risk of Atrial Fibrillation and cardioembolic stroke |
| Reference | GRCh38 38.1/141 |
| Chromosome | 4 |
| Position | 110799605 |
| is a | snp |
| is | mentioned by |
| dbSNP | rs10033464 |
| dbSNP (classic) | rs10033464 |
| ClinGen | rs10033464 |
| ebi | rs10033464 |
| HLI | rs10033464 |
| Exac | rs10033464 |
| Gnomad | rs10033464 |
| Varsome | rs10033464 |
| LitVar | rs10033464 |
| Map | rs10033464 |
| PheGenI | rs10033464 |
| Biobank | rs10033464 |
| 1000 genomes | rs10033464 |
| hgdp | rs10033464 |
| ensembl | rs10033464 |
| geneview | rs10033464 |
| scholar | rs10033464 |
| rs10033464 | |
| pharmgkb | rs10033464 |
| gwascentral | rs10033464 |
| openSNP | rs10033464 |
| 23andMe | rs10033464 |
| SNPshot | rs10033464 |
| SNPdbe | rs10033464 |
| MSV3d | rs10033464 |
| GWAS Ctlg | rs10033464 |
| GMAF | 0.1635 |
| Max Magnitude | 3 |
| ? | (G;G) (G;T) (T;T) | 28 |
|---|---|---|
|
| ||
Two SNPs from chromosome 4q25, rs2200733 and rs10033464, were found to be associated with atrial fibrillation in a study of both European and Asian populations. The odds ratio associated with one or more copies of either risk allele was ~1.4x.[PMID 17603472]
[PMID 18991354] In 1,661 Icelandic ischemic stroke samples and two large European replication sets combined, rs10033464 was associated with cardioembolic stroke (CES) (odds ratio 1.27, p = 6.1 x 10e-4).
[PMID 19141561
] rs2200733 and rs10033464 are strongly associated with AF in four cohorts of European descent.
| GWAS | |
|---|---|
| SNP | rs10033464 |
| PubMedID | [PMID 17603472] |
| Condition | Atrial fibrillation/atrial flutter |
| Gene | PITX2,ENPEP |
| Risk Allele | T |
| pValue | 7.00E-011 |
| OR | 1.39 |
| 95% CI | 1.26-1.53 |
[PMID 21414601] Usefulness of Single Nucleotide Polymorphism in Chromosome 4q25 to Predict In-Hospital and Long-Term Development of Atrial Fibrillation and Survival in Patients Undergoing Coronary Artery Bypass Grafting
[PMID 21760908] Association between variants on chromosome 4q25, 16q22 and 1q21 and atrial fibrillation in the Polish population
[PMID 20031626] Variation in the 4q25 chromosomal locus predicts atrial fibrillation after coronary artery bypass graft surgery.
[PMID 20170812] Chromosome 4q25 variants and atrial fibrillation recurrence after catheter ablation.
[PMID 20173747] Common variants in KCNN3 are associated with lone atrial fibrillation.
[PMID 20606429] Association of RS2200733 but not RS10033464 on 4q25 with atrial fibrillation based on the recessive model in a Taiwanese population.
[PMID 20671249] The association of the 4q25 susceptibility variant for atrial fibrillation with stroke is limited to stroke of cardioembolic etiology.
[PMID 20676228] Lone AF - etiologic factors and genetic insights into pathophysiolgy.
[PMID 22726630] Symptomatic response to antiarrhythmic drug therapy is modulated by a common single nucleotide polymorphism in atrial fibrillation.
[PMID 22818067] Chromosome 4q25 variants are genetic modifiers of rare ion channel mutations associated with familial atrial fibrillation.
[PMID 23178686] Common atrial fibrillation risk alleles at 4q25 predict recurrence after catheter-based atrial fibrillation ablation.
[PMID 23428961] Common genetic polymorphism at 4q25 locus predicts atrial fibrillation recurrence after successful cardioversion.
[PMID 24065534] Rs2200733 and rs10033464 on chromosome 4q25 confer risk of cardioembolic stroke: an updated meta-analysis
[PMID 25684755] Common Genetic Variants and Response to Atrial Fibrillation Ablation
[PMID 26005361] Association of common variations on chromosome 4q25 and left atrial volume in patients with atrial fibrillation
[PMID 29624624] Genetic modulation of atrial fibrillation risk in a Hispanic/Latino cohort.
