rs10008492

plus

Geno	Mag	Summary
(C;C)		normal
(C;T)		Very small 1.1x increased risk for Non-hodgkin's lymphoma
(T;T)		1.4x increased risk for Non-hodgkin's lymphoma

Reference

GRCh38 38.1/141

Chromosome

4

Position

38764099

is a	snp
is	mentioned by
dbSNP	rs10008492
dbSNP (classic)	rs10008492
ClinGen	rs10008492
ebi	rs10008492
HLI	rs10008492
Exac	rs10008492
Gnomad	rs10008492
Varsome	rs10008492
LitVar	rs10008492
Map	rs10008492
PheGenI	rs10008492
Biobank	rs10008492
1000 genomes	rs10008492
hgdp	rs10008492
ensembl	rs10008492
geneview	rs10008492
scholar	rs10008492
google	rs10008492
pharmgkb	rs10008492
gwascentral	rs10008492
openSNP	rs10008492
23andMe	rs10008492
SNPshot	rs10008492
SNPdbe	rs10008492
MSV3d	rs10008492
GWAS Ctlg	rs10008492

GMAF

0.2576

Max Magnitude

0

?

(C;C) (C;T) (T;T)

28

rs10008492 is a SNP located in a cluster of toll-like receptor genes.

In a pooled analysis including three population-based case-control studies of Non-Hodgkin's lymphoma (1,946 cases, 1,808 controls), two SNPs in moderate linkage disequilibrium were significantly associated with NHL: rs10008492 (odds ratio for (C;T) genotype 1.12, CI: 0.97-1.30; OR(T;T) 1.40, CI: 1.15-1.71; p(trend)=0.001) and rs4833103 (OR(A;C) 0.75, CI: 0.64-0.88; OR(A;A) 0.74, CI: 0.62-0.90; p(trend)=0.002; p(dominant)=0.0002).[PMID 19029192 ]

[PMID 19503599 ] The impact of divergence time on the nature of population structure: an example from Iceland.

[PMID 20200442 ] Sequence variants in the TLR4 and TLR6-1-10 genes and prostate cancer risk. Results based on pooled analysis from three independent studies.

[PMID 21872627] Association of polymorphisms in TLR genes and in genes of the Toll-like receptor signaling pathway with cancer risk.