Haplogroup I (Y-DNA)
Haplogroup I (Y-DNA) is a Y chromosome clade. A clade represents all the branches - and thus descendants - of an taxonomic (or ancestral) tree that share a single common ancestor.Wikipedia
Y-DNA Haplogroup I represents one of the twenty major branches of the Y chromosome as defined by the Y Chromosome Consortium (YCC2008). Nearly one out of five Europeans is a member. Haplogroup I probably arose in Europe because it is almost non-existent outside of Europe.
Y-DNA Haplogroup I represents one of two major European Y chromosome haplogroups (the other major haplogroup is Y Haplogroup R). Unlike R, clade I is widespread in Europe and is virtually absent elsewhere. Subclade Haplogroup I1 (Y-DNA)) is found mostly in Northern Europe, while subclade Haplogroup I2 (Y-DNA) is the most frequent haplogroup in Eastern Europe and the Balkans.[PMID 18385274]
A study of 3,000+ British men concluded that carriers of haplogroup I had about a 50% higher age-adjusted risk of coronary artery disease than did men with other Y haplogroups (for the combined populations, with an odds ratio of 1.56, CI:1.24—1.97, p=0·0002). The association between haplogroup I and coronary artery disease was independent of traditional cardiovascular and socioeconomic risk factors.[PMID 22325189] However 23andMe disputes the link to coronary artery disease.
Y-DNA Haplogroup I is now defined by eight mutations: See ISOGG 2011
- M170 = rs2032597(C;C)
- M258 = rs9341301(C;C)
- P38 = i4000186(C;C)
- P212 = i4000163(A;A)
- U179 = rs2319818(A;A)
This haplogroup is defined in genoset Gs196.
P19 is not a SNP but a set of multiple mutations in DYS190.