HLA-E is gene for a non-classical HLA antigen, with 2 functional variants. It has been connected to multiple cancer prognoses.
HLA-E*0103X is associated with susceptibility to Pemphigus vulgaris and Behcet's disease. E *0101/*0103X is associated with childhood onset diabetes[PMID 23362868]
HLA-E*0101 was associated with hepatitis C clearance in HIV patients with interaction of rs8099917. [PMID 23811951]
HLA-E O1:01 and HLA-E 01:03 have been connected to psoriasis, dependent on HLA-C.[PMID 24279916]
HLA-E genotype was associated with CMV infection after bone marrow transplant [PMID 23998599].
HLA-E*0103/0103 may be protective in allogeneic hematopoietic stem cell transplant [PMID 23395341].